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A controlled chamber study of effects of exposure to diesel exhaust particles and noise on heart rate variability and endothelial function
University of Gothenburg, Sweden; Sahlgrenska University Hospital, Sweden.
University of Gothenburg, Sweden; Sahlgrenska University Hospital, Sweden.
Lund University, Sweden.
RISE Research Institutes of Sweden, Bioeconomy and Health, Material and Surface Design. Lund University, Sweden.ORCID iD: 0000-0001-8650-4741
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2022 (English)In: Inhalation Toxicology, ISSN 0895-8378, E-ISSN 1091-7691, Vol. 34, no 5-6, p. 159-170Article in journal (Refereed) Published
Abstract [en]

Background: Adverse cardiovascular effects are associated with both diesel exhaust and road traffic noise, but these exposures are hard to disentangle epidemiologically. We used an experimental setup to evaluate the impact of diesel exhaust particles and traffic noise, alone and combined, on intermediary outcomes related to the autonomic nervous system and increased cardiovascular risk. Methods: In a controlled chamber 18 healthy adults were exposed to four scenarios in a randomized cross-over fashion. Each exposure scenario consisted of either filtered (clean) air or diesel engine exhaust (particle mass concentrations around 300 µg/m3), and either low (46 dB(A)) or high (75 dB(A)) levels of traffic noise for 3 h at rest. ECG was recorded for 10-min periods before and during each exposure type, and frequency-domain heart rate variability (HRV) computed. Endothelial dysfunction and arterial stiffness were assessed after each exposure using EndoPAT 2000. Results: Compared to control exposure, HRV in the high frequency band decreased during exposure to diesel exhaust, both alone and combined with noise, but not during noise exposure only. These differences were more pronounced in women. We observed no synergistic effects of combined exposure, and no significant differences between exposure scenarios for other HRV indices, endothelial function or arterial stiffness. Conclusion: Three-hour exposure to diesel exhaust, but not noise, was associated with decreased HRV in the high frequency band. This indicates activation of irritant receptor-mediated autonomic reflexes, a possible mechanism for the cardiovascular risks of diesel exposure. There was no effect on endothelial dysfunction or arterial stiffness after exposure. © 2022 The Author(s). 

Place, publisher, year, edition, pages
Taylor and Francis Ltd. , 2022. Vol. 34, no 5-6, p. 159-170
Keywords [en]
aerosol, cardiovascular, Diesel, endothelial function, heart rate variability, noise, PM1, adult, analysis, cardiovascular system, chemistry, controlled study, exhaust gas, female, heart rate, human, lung, particulate matter, randomized controlled trial, toxicity, Humans, Vehicle Emissions
National Category
Renewable Bioenergy Research
Identifiers
URN: urn:nbn:se:ri:diva-59349DOI: 10.1080/08958378.2022.2065388Scopus ID: 2-s2.0-85129860513OAI: oai:DiVA.org:ri-59349DiVA, id: diva2:1669515
Note

 Funding details: ALFGBG-77990; Funding details: Forskningsrådet för Arbetsliv och Socialvetenskap, FAS; Funding details: Svenska Forskningsrådet Formas, 216-2007-1207; Funding details: Lunds Universitet; Funding details: Forskningsrådet om Hälsa, Arbetsliv och Välfärd, FORTE; Funding text 1: This study was financed by the Swedish Research Council FORMAS [216-2007-1207] and performed within the framework of Metalund, the Centre for Medicine and Technology for Working Life and Society, a competence centre at Lund University, Sweden, supported by FAS/Forte, the Swedish Council for Working Life and Social Research. L.S. was funded by the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement [ALFGBG-77990]. We thank all the study subjects for participating in the study.

Available from: 2022-06-14 Created: 2022-06-14 Last updated: 2023-05-22Bibliographically approved

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