Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Anti-colonization effect of au surfaces with self-assembled molecular monolayers functionalized with antimicrobial peptides on s. Epidermidis
Amicoat AS, Norway; Arctic University of Norway, Norway.
Amicoat AS, Norway: Arctic University of Norway, Norway.
Arctic University of Norway, Norway.
RISE Research Institutes of Sweden.ORCID iD: 0000-0002-4729-9359
Show others and affiliations
2021 (English)In: Antibiotics, ISSN 0066-4774, E-ISSN 2079-6382, Vol. 10, no 12, article id 1516Article in journal (Refereed) Published
Abstract [en]

Medical devices with an effective anti-colonization surface are important tools for com-batting healthcare-associated infections. Here, we investigated the anti-colonization efficacy of antimicrobial peptides covalently attached to a gold model surface. The gold surface was modified by a self-assembled polyethylene glycol monolayer with an acetylene terminus. The peptides were covalently connected to the surface through a copper-catalyzed [3 + 2] azide-acetylene coupling (CuAAC). The anti-colonization efficacy of the surfaces varied as a function of the antimicrobial activity of the peptides, and very effective surfaces could be prepared with a 6 log unit reduction in bacterial colonization. © 2021 by the authors. 

Place, publisher, year, edition, pages
MDPI , 2021. Vol. 10, no 12, article id 1516
Keywords [en]
Anti-colonization, Antifouling, Antimicrobial peptide, Antimicrobial surface, Certika, Self-assembled monolayer, ToF-SIMS imaging, acetylene, copper, dichloromethane, gold, macrogol, macrogol 200, macrogol 400, phenylalanine, polypeptide antibiotic agent, self assembled monolayer, tryptophan, antibiotic sensitivity, antimicrobial activity, Article, bacterial colonization, colony forming unit, column chromatography, drug synthesis, electrospray mass spectrometry, Escherichia coli, Gram negative bacterium, healthcare associated infection, high performance liquid chromatography, lipophilicity, minimum inhibitory concentration, nonhuman, proton nuclear magnetic resonance, Staphylococcus epidermidis, time of flight mass spectrometry
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:ri:diva-57900DOI: 10.3390/antibiotics10121516Scopus ID: 2-s2.0-85121753149OAI: oai:DiVA.org:ri-57900DiVA, id: diva2:1626020
Note

 Funding details: Norges Forskningsråd, 283272; Funding text 1: This research was funded by Amicoat AS and the Research Council of Norway, grant number 283272.

Available from: 2022-01-10 Created: 2022-01-10 Last updated: 2023-05-25Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopus

Authority records

Svenson, JohanBerglin, Mattias

Search in DiVA

By author/editor
Svenson, JohanBerglin, Mattias
By organisation
RISE Research Institutes of SwedenProduct Realisation Methodology
In the same journal
Antibiotics
Biomaterials Science

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 96 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf