Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Molecular Response to Nanopatterned Implants in the Human Jaw Bone
University of Gothenburg, Sweden.
Imam Abdulrahman Bin Faisal University, Saudi Arabia.
RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning.ORCID-id: 0000-0003-4592-5851
University of Gothenburg, Sweden.
Vise andre og tillknytning
2021 (engelsk)Inngår i: ACS Biomaterials Science & Engineering, E-ISSN 2373-9878, Vol. 7, nr 12, s. 5878-5889Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Implant surface modification by nanopatterning is an interesting route for enhancing osseointegration in humans. Herein, the mol. response to an intentional, controlled nanotopog. pattern superimposed on screw-shaped titanium implants is investigated in human bone. When clin. implants are installed, addnl. two mini-implants, one with a machined surface (M) and one with a machined surface superimposed with a hemispherical nanopattern (MN), are installed in the posterior maxilla. In the second-stage surgery, after 6-8 wk, the mini-implants are retrieved by unscrewing, and the implant-adherent cells are subjected to gene expression anal. using quant. polymerase chain reaction (qPCR). Compared to those adherent to the machined (M) implants, the cells adherent to the nanopatterned (MN) implants demonstrate significant upregulation (1.8- to 2-fold) of bone-related genes (RUNX2, ALP, and OC). No significant differences are observed in the expression of the analyzed inflammatory and remodeling genes. Correlation anal. reveals that older patient age is associated with increased expression of proinflammatory cytokines (TNF-α and MCP-1) on the machined implants and decreased expression of pro-osteogenic factor (BMP-2) on the nanopatterned implants. Controlled nanotopog., in the form of hemispherical 60 nm protrusions, promotes gene expressions related to early osteogenic differentiation and osteoblastic activity in implant-adherent cells in the human jaw bone.

sted, utgiver, år, opplag, sider
American Chemical Society , 2021. Vol. 7, nr 12, s. 5878-5889
Emneord [en]
gene expression, human jaw, nanomedicine, nanotopography, osseointegration, osteogenic activities
HSV kategori
Identifikatorer
URN: urn:nbn:se:ri:diva-57561DOI: 10.1021/acsbiomaterials.1c00861OAI: oai:DiVA.org:ri-57561DiVA, id: diva2:1625489
Tilgjengelig fra: 2022-01-07 Laget: 2022-01-07 Sist oppdatert: 2023-06-07bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekst

Person

Petronis, Sarunas

Søk i DiVA

Av forfatter/redaktør
Petronis, Sarunas
Av organisasjonen
I samme tidsskrift
ACS Biomaterials Science & Engineering

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 35 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
v. 2.43.0