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Oxygenated Nanocellulose - A Material Platform for Antibacterial Wound Dressing Devices
Oxy Solutions, Norway.
RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology.ORCID iD: 0009-0004-4933-6629
RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology.ORCID iD: 0000-0003-4592-5851
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2021 (English)In: ACS Applied Bio Materials, E-ISSN 2576-6422, Vol. 4, no 10, p. 7554-7562Article in journal (Refereed) Published
Abstract [en]

Both carboxylated cellulose nanofibrils (CNF) and dissolved oxygen (DO) have been reported to possess antibacterial properties. However, the combination for use as wound dressings against biofilm infections in chronic wounds is less known. The present study reports the development of oxygenated CNF dispersions that exhibit strong antibacterial effect. Carboxylated CNF dispersions with different oxidation levels were oxygenated by the OXY BIO System and tested for antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus. The results reveal that the higher oxidation level of the CNFs, the better antibacterial effect. Scanning electron microscopy of bacterial biofilms revealed that a potential mechanism of action of the CNFs is the formation of a network surrounding and entrapping the bacteria. This effect is further potentiated by the oxygenation process. A CNF sample (concentration 0.6 wt %) that was oxygenated to a DO level of 46.4 mg/L demonstrated a strong antibacterial effect against S. aureus in vivo using a mouse model of surgical site infection. The oxygenated CNF dispersion reduced the bacterial survival by 71%, after 24 h treatment. The potent antibacterial effect indicates that oxygenated nanocellulose is a promising material for antibacterial wound dressings. © 2021 The Authors.

Place, publisher, year, edition, pages
American Chemical Society , 2021. Vol. 4, no 10, p. 7554-7562
Keywords [en]
antibacterial properties, biofilm infections, hyperoxia, nanocellulose, topical dressings, wound healing, Biofilms, Dispersions, Dissolved oxygen, Scanning electron microscopy, Antibacterial effects, Antibacterials, Cellulose nanofibrils, Nano-cellulose, Topical dressing, Wound dressings, Bacteria, Diseases, Formation, Oxidation, Processes, Surgical Dressings, Survival
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:ri:diva-56894DOI: 10.1021/acsabm.1c00819Scopus ID: 2-s2.0-85117321748OAI: oai:DiVA.org:ri-56894DiVA, id: diva2:1613524
Note

 Funding details: Norges Forskningsråd, 283895, 309178; Funding text 1: This work was partly funded by the MANUNET III program (Project No. MNET17/NMCS-1204) and Research Council of Norway Grant No. 283895, MedIn project (“New functionalized medical devices for surgical interventions in the pelvic cavity”, Grant No. 283895), and the OxyPol project (“Oxygenated biopolymers for biomedical applications”, Grant No. 309178).

Available from: 2021-11-22 Created: 2021-11-22 Last updated: 2023-11-21Bibliographically approved

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Agrenius, KarinPetronis, SarunasHåkansson, JoakimChinga-Carrasco, Gary

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