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In vitro and in vivo antibacterial properties of peptide AMC-109 impregnated wound dressings and gels
RISE Research Institutes of Sweden, Materials and Production, Chemistry, Biomaterials and Textiles. Gothenburg University, Sweden.ORCID iD: 0000-0002-4270-8475
Amicoat A/S, Norway; UiT The Arctic University of Norway, Norway.
UiT The Arctic University of Norway, Norway.
Amicoat A/S, Norway.
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2021 (English)In: Journal of Antibiotics, ISSN 0021-8820, E-ISSN 1881-1469, Vol. 74, p. 337-345Article in journal (Refereed) Published
Abstract [en]

Synthetic mimics of antimicrobial peptides (AMPs) is a promising class of molecules for a variety of antimicrobial applications. Several hurdles must be passed before effective systemic infection therapies with AMPs can be achieved, but the path to effective topical treatment of skin, nail, and soft tissue infections appears less challenging to navigate. Skin and soft tissue infection is closely coupled to the emergence of antibiotic resistance and represents a major burden to the healthcare system. The present study evaluates the promising synthetic cationic AMP mimic, AMC-109, for treatment of skin infections in vivo. The compound is evaluated both in impregnated cotton wound dressings and in a gel formulation against skin infections caused by Staphylococcus aureus and methicillin resistant S. aureus. Both the ability to prevent colonization and formation of an infection, as well as eradicate an ongoing infection in vivo with a high bacterial load, were evaluated. The present work demonstrates that AMC-109 displays a significantly higher antibacterial activity with up to a seven-log reduction in bacterial loads compared to current clinical standard therapy; Altargo cream (1% retapamulin) and Fucidin cream (2% fusidic acid) in the in vivo wound models. It is thus concluded that AMC-109 represents a promising entry in the development of new and effective remedies for various skin infections. © 2021, The Author(s)

Place, publisher, year, edition, pages
Springer Nature , 2021. Vol. 74, p. 337-345
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Natural Sciences
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URN: urn:nbn:se:ri:diva-52240DOI: 10.1038/s41429-021-00406-5Scopus ID: 2-s2.0-85099971826OAI: oai:DiVA.org:ri-52240DiVA, id: diva2:1526021
Note

Funding details: Norges Forskningsråd; Funding text 1: Acknowledgements This work was partly supported by the BIA— User-driven Research-based Innovation Project Program (Grant Number 281949) from the Research Council of Norway.

Available from: 2021-02-05 Created: 2021-02-05 Last updated: 2023-05-22Bibliographically approved

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Håkansson, JoakimSvenson, Johan

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