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Intracellular Fate of Hydrophobic Nanocrystal Self-Assemblies in Tumor Cells
Université de Paris, France.
Shandong University, China.
KTH Royal Institute of Technology, Sweden.ORCID iD: 0000-0001-6877-9282
Université de Paris, France.
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2020 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Vol. 30, no 40, article id 2004274Article in journal (Refereed) Published
Abstract [en]

Control of interactions between nanomaterials and cells remains a biomedical challenge. A strategy is proposed to modulate the intralysosomal distribution of nanoparticles through the design of 3D suprastructures built by hydrophilic nanocrystals (NCs) coated with alkyl chains. The intracellular fate of two water-dispersible architectures of self-assembled hydrophobic magnetic NCs: hollow deformable shells (colloidosomes) or solid fcc particles (supraballs) is compared. These two self-assemblies display increased cellular uptake by tumor cells compared to dispersions of the water-soluble NC building blocks. Moreover, the self-assembly structures increase the NCs density in lysosomes and close to the lysosome membrane. Importantly, the structural organization of NCs in colloidosomes and supraballs are maintained in lysosomes up to 8 days after internalization, whereas initially dispersed hydrophilic NCs are randomly aggregated. Supraballs and colloidosomes are differently sensed by cells due to their different architectures and mechanical properties. Flexible and soft colloidosomes deform and spread along the biological membranes. In contrast, the more rigid supraballs remain spherical. By subjecting the internalized suprastructures to a magnetic field, they both align and form long chains. Overall, it is highlighted that the mechanical and topological properties of the self-assemblies direct their intracellular fate allowing the control intralysosomal density, ordering, and localization of NCs. 

Place, publisher, year, edition, pages
Wiley-VCH Verlag , 2020. Vol. 30, no 40, article id 2004274
Keywords [en]
artificial colloidal crystals, intracellular fate, magnetic manipulation, nano-biointeractions, nanocrystal self-assembly, Biological membranes, Biomechanics, Cells, Cytology, Hydrophilicity, Hydrophobicity, Nanocrystals, Self assembly, Topology, Tumors, Building blockes, Cellular uptake, Hydrophilic nanocrystals, Hydrophobic nanocrystals, Self-assembly structure, Structural organization, Topological properties, Water dispersible, Sols
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-46835DOI: 10.1002/adfm.202004274Scopus ID: 2-s2.0-85089453406OAI: oai:DiVA.org:ri-46835DiVA, id: diva2:1460598
Note

Funding details: Fondation ARC pour la Recherche sur le Cancer, ARC; Funding text 1: F.G. and M.P.P. contributed equally to this work. Dr. J. Teixeira from Laboratoire Leon Brillouin CEA Saclay is thanked for fruitful discussions on SAXS measurement. Dr. J.M. Guinier is thanked for cryoTEM experiments. A.N.‐B. received a Ph.D. fellowship from the Institute thematique multi‐organismes (ITMO) Cancer and the doctoral school Frontières du Vivant (FdV)—Programme Bettencourt and the Fondation ARC pour la recherche sur le cancer.

Available from: 2020-08-24 Created: 2020-08-24 Last updated: 2023-03-30Bibliographically approved

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Dobryden, Illia

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