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Riveting hammer vibration damages mechanosensory nerve endings
Medical College of WI, USA.
Medical College of WI, USA.
Medical College of WI, USA.
RISE Research Institutes of Sweden, Materials and Production, Manufacturing Processes.ORCID iD: 0000-0001-5361-440x
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2020 (English)In: Journal of the peripheral nervous system, ISSN 1085-9489, E-ISSN 1529-8027, Vol. 25, no 3, p. 279-287Article in journal (Refereed) Published
Abstract [en]

Background and Aims Hand-arm vibration syndrome (HAVS) is an irreversible neurodegenerative, vasospastic and musculoskeletal occupational disease of workers using powered hand tools. The etiology is poorly understood. Neurological symptoms include numbness, tingling and pain. This study examines impact hammer vibration-induced injury and recoverability of hair mechanosensory innervation. Methods Rat tails were vibrated 12?min/d for 5 wk followed by 5 wk recovery with synchronous non-vibrated controls. Nerve fibers were PGP9.5 immunostained. Lanceolate complex innervation was compared quantitatively in vibrated vs sham. Vibration peak acceleration magnitudes were characterized by frequency power spectral analysis. Results Average magnitude (2515?m/s2, rms) in kHz frequencies was 109 times that (23?m/s2) in low Hz. Percentage of hairs innervated by lanceolate complexes was 69.1% in 5wk sham and 53.4% in 5wk vib generating a denervation difference of 15.7% higher in vibration. Hair innervation was 76.9% in 5wk recovery sham and 62.0% in 5wk recovery vibration producing a denervation difference 14.9% higher in recovery vibration. Lanceolate number per complex (18.4?±?0.2) after vibration remained near sham (19.3?±?0.3), but 44.9% of lanceolate complexes were abnormal in 5 wk vibrated compared to 18.8% in sham. Interpretation The largest vibration energies are peak kHz accelerations (~?100?000?m/s2) from shock waves. The existing ISO 5349-1 standard excludes kHz vibrations, seriously underestimating vibration injury risk. The present study validates the rat-tail, impact hammer vibration as a model for investigating irreversible nerve damage. Persistence of higher denervation difference after 5-week recovery suggests repeated vibration injury destroys the capability of lanceolate nerve endings to regenerate. 

Place, publisher, year, edition, pages
John Wiley & Sons, Ltd , 2020. Vol. 25, no 3, p. 279-287
Keywords [en]
denervation, mechanosensory, neurodegeneration, PGP9.5, shock wave, vibration disease
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-45035DOI: 10.1111/jns.12393OAI: oai:DiVA.org:ri-45035DiVA, id: diva2:1433002
Conference
7th American Conference on Human Vibration, Seattle, WA on June 13, 2018
Available from: 2020-05-28 Created: 2020-05-28 Last updated: 2023-09-21Bibliographically approved

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Publisher's full texthttps://doi.org/10.1111/jns.12393

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Lindell, HansGretarsson, Snaevar

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