This review article analyzes factors affecting emergency response to hazardous events on highways and their bridges, with focus on man-made and natural scenarios: heavy vehicle collision with a bridge, earthquake, heavy snowfall, and flooding. For each disaster scenario, selected historical events were compiled to determine influential factors and success criteria for efficient emergency response, both related to organizational and technical measures. This study constituted a part of a resilience management process, recently developed and demonstrated within the European Union (EU)-funded H2020 project IMPROVER and can be a useful approach in aiding operators of transportation infrastructure to improve their resilience to emergency incidents.