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Propofol adsorption at the air/water interface: a combined vibrational sum frequency spectroscopy, nuclear magnetic resonance and neutron reflectometry study
RISE - Research Institutes of Sweden, Bioscience and Materials, Surface, Process and Formulation.ORCID iD: 0000-0003-0195-3850
RISE - Research Institutes of Sweden, Bioscience and Materials, Surface, Process and Formulation.
RISE - Research Institutes of Sweden, Bioscience and Materials, Surface, Process and Formulation. KTH Royal Institute of Technology, Sweden.ORCID iD: 0000-0002-6394-6990
RISE - Research Institutes of Sweden, Bioscience and Materials, Surface, Process and Formulation. KTH Royal Institute of Technology, Sweden.
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2019 (English)In: Soft Matter, ISSN 1744-683X, E-ISSN 1744-6848, Vol. 15, no 1, p. 38-46Article in journal (Refereed) Published
Abstract [en]

Propofol is an amphiphilic small molecule that strongly influences the function of cell membranes, yet data regarding interfacial properties of propofol remain scarce. Here we consider propofol adsorption at the air/water interface as elucidated by means of vibrational sum frequency spectroscopy (VSFS), neutron reflectometry (NR), and surface tensiometry. VSFS data show that propofol adsorbed at the air/water interface interacts with water strongly in terms of hydrogen bonding and weakly in the proximity of the hydrocarbon parts of the molecule. In the concentration range studied there is almost no change in the orientation adopted at the interface. Data from NR show that propofol forms a dense monolayer with a thickness of 8.4 Å and a limiting area per molecule of 40 Å2, close to the value extracted from surface tensiometry. The possibility that islands or multilayers of propofol form at the air/water interface is therefore excluded as long as the solubility limit is not exceeded. Additionally, measurements of the 1H NMR chemical shifts demonstrate that propofol does not form dimers or multimers in bulk water up to the solubility limit.

Place, publisher, year, edition, pages
2019. Vol. 15, no 1, p. 38-46
Keywords [en]
Cytology, Dimers, Hydrogen bonds, Interferometry, Molecules, Neutron reflection, Nuclear magnetic resonance, Nuclear magnetic resonance spectroscopy, Reflection, Reflectometers, Solubility, Air/Water Interfaces, Concentration ranges, Interfacial property, Neutron reflectometry, NMR chemical shifts, Solubility limits, Surface tensiometry, Vibrational sum-frequency spectroscopies, Phase interfaces
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Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-37020DOI: 10.1039/C8SM01677AScopus ID: 2-s2.0-85058894693OAI: oai:DiVA.org:ri-37020DiVA, id: diva2:1280061
Note

Funding details: U.S. Department of the Interior, TEST-2589; Funding details: Institute for Translational Neuroscience, ITN;

Available from: 2019-01-17 Created: 2019-01-17 Last updated: 2019-03-07Bibliographically approved

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Niga, PetruSwerin, Agne

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