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Label free urea biosensor based on organic electrochemical transistors
Università di Modena e Reggio Emilia, Italy.
Linköping University, Sweden.
RISE - Research Institutes of Sweden, ICT, Acreo. Linköping University, Sweden.ORCID iD: 0000-0002-0772-439x
Università di Modena e Reggio Emilia, Italy.
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2018 (English)In: Flexible and Printed Electronics, ISSN 2058-8585, Vol. 3, no 2, article id 024001Article in journal (Refereed) Published
Abstract [en]

The quantification of urea is of the utmost importance not only in medical diagnosis, where it serves as a potential indicator of kidney and liver disfunction, but also in food safety and environmental control. Here, we describe a urea biosensor based on urease entrapped in a crosslinked gelatin hydrogel, deposited onto a fully printed PEDOT:PSS-based organic electrochemical transistor (OECT). The device response is based on the modulation of the channel conductivity by the ionic species produced upon urea hydrolysis catalyzed by the entrapped urease. The biosensor shows excellent reproducibility, a limit of detection as low as 1 μM and a response time of a few minutes. The fabrication of the OECTs by screen-printing on flexible substrates ensures a significant reduction in manufacturing time and costs. The low dimensionality and operational voltages (0.5 V or below) of these devices contribute to make these enzymatic OECT-based biosensors as appealing candidates for high-throughput monitoring of urea levels at the point-of-care or in the field.

Place, publisher, year, edition, pages
2018. Vol. 3, no 2, article id 024001
Keywords [en]
gelatin, OECT, organic bioelectronics, screen-printing, urease, Biosensors, Conducting polymers, Diagnosis, Environmental management, Screen printing, Substrates, Urea, Cross-linked gelatins, Environmental control, Organic electrochemical transistors, Potential indicators, Metabolism
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-34442DOI: 10.1088/2058-8585/aac8a8Scopus ID: 2-s2.0-85049806215OAI: oai:DiVA.org:ri-34442DiVA, id: diva2:1237282
Note

 Funding for CD, VB, DTS and MB was provided by the Swedish Foundation for Strategic Research (Smart Intra-body network; grant RIT15-0119) for the financial support. Funding for LT was provided by the BIORAPID project (EU H2020 Marie Sklodowska-Curie grant agreement No. 643056) for financial support. CAB acknowledges the ‘Fondazione di Vig-nola’ for support. The authors would also like to acknowledge Ms Marie Nilsson for mask design and OECT fabrication.

Available from: 2018-08-08 Created: 2018-08-08 Last updated: 2019-01-02Bibliographically approved

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