Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Cytocompatibility of Wood-Derived Cellulose Nanofibril Hydrogels with Different Surface Chemistry
University of Bergen, Norway.
University of Bergen, Norway.
RISE - Research Institutes of Sweden, Bioekonomi, PFI.ORCID-id: 0000-0001-8876-8898
RISE - Research Institutes of Sweden, Bioekonomi, PFI. NTNU Norwegian University of Science and Technology, Norway.ORCID-id: 0000-0003-2271-3637
2017 (engelsk)Inngår i: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 18, nr 4, s. 1238-1248Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The current study aims to demonstrate the influence of the surface chemistry of wood-derived cellulose nanofibril (CNF) hydrogels on fibroblasts for tissue engineering applications. TEMPO-mediated oxidation or carboxymethylation pretreatments were employed to produce hydrogels with different surface chemistry. This study demonstrates the following: first, the gelation of CNF with cell culture medium and formation of stable hydrogels with improved rheological properties; second, the response of mouse fibroblasts cultured on the surface of the hydrogels or sandwiched within the materials with respect to cytotoxicity, cell attachment, proliferation, morphology, and migration. Indirect cytotoxicity tests showed no toxic effect of either hydrogel. The direct contact with the carboxymethylated hydrogel adversely influenced the morphology of the cells and limited their spreading, while typical morphology and spreading of cells were observed with the TEMPO-oxidized hydrogel. The porous fibrous structure may be a key to cell proliferation and migration in the hydrogels.

sted, utgiver, år, opplag, sider
2017. Vol. 18, nr 4, s. 1238-1248
Emneord [en]
Cell culture, Cell proliferation, Cells, Cellulose, Cytology, Fibroblasts, Gelation, Morphology, Nanofibers, Surface chemistry, Tissue engineering, Wood, Carboxymethylation, Cell culture mediums, Cytotoxicity test, Fibrous structures, Rheological property, TEMPO-mediated oxidation, Tissue engineering applications, Typical morphology, Hydrogels, cross linking reagent, divalent cation, lactate dehydrogenase, biomaterial, hydrogel, nanomaterial, animal cell, Article, atomic force microscopy, biocompatibility, bioprinting, cell adhesion, cell encapsulation, cell interaction, cell migration, cell migration assay, cell structure, cell viability, chemical bond, controlled study, cross linking, culture medium, cytocompatibility, cytoskeleton, cytotoxicity, extracellular matrix, fibroblast, hydrogen bond, methylation, mouse, MTT assay, nonhuman, oxidation, priority journal, scanning electron microscopy, surface property, tissue culture, wood derived cellulose nanofibril hydrogel, animal, cell motion, cell survival, chemistry, flow kinetics, infrared spectroscopy, porosity, Surface Properties, Animals, Biocompatible Materials, Cell Movement, Cells, Cultured, Mice, Nanostructures, Rheology, Spectroscopy, Fourier Transform Infrared
HSV kategori
Identifikatorer
URN: urn:nbn:se:ri:diva-33166DOI: 10.1021/acs.biomac.6b01911Scopus ID: 2-s2.0-85018467340OAI: oai:DiVA.org:ri-33166DiVA, id: diva2:1176692
Merknad

 Funding details: AFM, Association Française contre les Myopathies; Funding details: 245963/F50; Funding details: 302077, Helse Vest;Funding details: NTNU, National Taiwan Normal University; Funding details: 228147, Norges Forskningsråd

Tilgjengelig fra: 2018-01-23 Laget: 2018-01-23 Sist oppdatert: 2019-01-07bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstScopus

Personposter BETA

Heggset, Ellinor BSyverud, Kristin

Søk i DiVA

Av forfatter/redaktør
Heggset, Ellinor BSyverud, Kristin
Av organisasjonen
I samme tidsskrift
Biomacromolecules

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 5 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
v. 2.35.9