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Continuously operating biosensor and its integration into a hermetically sealed medical implant
IHP Innovations for High Performance Microelectronics, Germany.
IHP Innovations for High Performance Microelectronics, Germany.
IHP Innovations for High Performance Microelectronics, Germany.
IHP Innovations for High Performance Microelectronics, Germany.
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2016 (English)In: Micromachines, ISSN 2072-666X, E-ISSN 2072-666X, Vol. 7, no 10, article id 183Article in journal (Refereed) Published
Abstract [en]

An integration concept for an implantable biosensor for the continuous monitoring of blood sugar levels is presented. The system architecture is based on technical modules used in cardiovascular implants in order to minimize legal certification efforts for its perspective usage in medical applications. The sensor chip operates via the principle of affinity viscometry, which is realized by a fully embedded biomedical microelectromechanical systems (BioMEMS) prepared in 0.25-μm complementary metal-oxide-semiconductor (CMOS)/BiCMOS technology. Communication with a base station is established in the 402-405 MHz band used for medical implant communication services (MICS). The implant shall operate within the interstitial tissue, and the hermetical sealing of the electronic system against interaction with the body fluid is established using titanium housing. Only the sensor chip and the antenna are encapsulated in an epoxy header closely connected to the metallic housing. The study demonstrates that biosensor implants for the sensing of low-molecular-weight metabolites in the interstitial may successfully rely on components already established in cardiovascular implantology.

Place, publisher, year, edition, pages
2016. Vol. 7, no 10, article id 183
Keywords [en]
Affinity assay, BioMEMS, Biosensor, Continuous glucose monitoring, Medical implant, Metallic housing, Sterilization, Titanium, Amorphous films, Biosensors, CMOS integrated circuits, Electromechanical devices, Embedded systems, Housing, Medical applications, MEMS, Metals, MOS devices, Oxide semiconductors, Sterilization (cleaning), Affinity assays, Biomedical microelectromechanical systems, Cardiovascular implants, Complementary metal oxide semiconductors, Implantable biosensors, Medical implant communication services, Medical implants, Bioassay
National Category
Computer and Information Sciences
Identifiers
URN: urn:nbn:se:ri:diva-32567DOI: 10.3390/mi7100183Scopus ID: 2-s2.0-84994893462OAI: oai:DiVA.org:ri-32567DiVA, id: diva2:1155611
Note

Funding details: 16SV3934, BMBF, Bundesministerium für Bildung und Forschung

Available from: 2017-11-08 Created: 2017-11-08 Last updated: 2019-06-13Bibliographically approved

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Theuer, Lorenz

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