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Integration of a droplet-based microfluidic system and silicon nanoribbon FET sensor
KTH Royal Institute of Technology, Sweden.
KTH Royal Institute of Technology, Sweden.
KTH Royal Institute of Technology, Sweden.
RISE., Swedish ICT, Acreo.
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2016 (Engelska)Ingår i: Micromachines, ISSN 2072-666X, E-ISSN 2072-666X, Vol. 7, nr 8, artikel-id 134Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

We present a novel microfluidic system that integrates droplet microfluidics with a silicon nanoribbon field-effect transistor (SiNR FET), and utilize this integrated system to sense differences in pH. The device allows for selective droplet transfer to a continuous water phase, actuated by dielectrophoresis, and subsequent detection of the pH level in the retrieved droplets by SiNR FETs on an electrical sensor chip. The integrated microfluidic system demonstrates a label-free detection method for droplet microfluidics, presenting an alternative to optical fluorescence detection. In this work, we were able to differentiate between droplet trains of one pH-unit difference. The pH-based detection method in our integrated system has the potential to be utilized in the detection of biochemical reactions that induce a pH-shift in the droplets.

Ort, förlag, år, upplaga, sidor
2016. Vol. 7, nr 8, artikel-id 134
Nyckelord [en]
Droplet microfluidics, NanoFET, PH measurement, Silicon nanoribbon, Drops, Electrophoresis, Field effect transistors, Fluidic devices, Integrated control, Nanoribbons, Silicon, Biochemical reactions, Droplet-based microfluidics, Integrated microfluidic systems, Label-free detection method, PH measurements, Microfluidics
Nationell ämneskategori
Data- och informationsvetenskap
Identifikatorer
URN: urn:nbn:se:ri:diva-32577DOI: 10.3390/mi7080134Scopus ID: 2-s2.0-84984791952OAI: oai:DiVA.org:ri-32577DiVA, id: diva2:1155595
Tillgänglig från: 2017-11-08 Skapad: 2017-11-08 Senast uppdaterad: 2019-06-14Bibliografiskt granskad

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