Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Solid nanofoams based on cellulose nanofibers and indomethacin—the effect of processing parameters and drug content on material structure
KTH Royal Institute of Technology, Sweden.
RISE - Research Institutes of Sweden, Biovetenskap och material, Kemi och material.
KTH Royal Institute of Technology, Sweden.
University of Copenhagen, Denmark.
Visa övriga samt affilieringar
2017 (Engelska)Ingår i: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 526, nr 1-2, s. 291-299Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The unique colloidal properties of cellulose nanofibers (CNF), makes CNF a very interesting new excipient in pharmaceutical formulations, as CNF in combination with some poorly-soluble drugs can create nanofoams with closed cells. Previous nanofoams, created with the model drug indomethacin, demonstrated a prolonged release compared to films, owing to the tortuous diffusion path that the drug needs to take around the intact air-bubbles. However, the nanofoam was only obtained at a relatively low drug content of 21 wt% using fixed processing parameters. Herein, the effect of indomethacin content and processing parameters on the foaming properties was analysed. Results demonstrate that a certain amount of dissolved drug is needed to stabilize air-bubbles. At the same time, larger fractions of dissolved drug promote coarsening/collapse of the wet foam. The pendant drop/bubble profile tensiometry was used to verify the wet-foam stability at different pHs. The pH influenced the amount of solubilized drug and the processing-window was very narrow at high drug loadings. The results were compared to real foaming-experiments and solid state analysis of the final cellular solids. The parameters were assembled into a processing chart, highlighting the importance of the right combination of processing parameters (pH and time-point of pH adjustment) in order to successfully prepare cellular solid materials with up to 46 wt% drug loading.

Ort, förlag, år, upplaga, sidor
Elsevier B.V. , 2017. Vol. 526, nr 1-2, s. 291-299
Nyckelord [en]
Cellulose nanofibers; Cellular solid material; Nanofoam; Indomethacin; Poorly-soluble drugs
Nationell ämneskategori
Kemiteknik
Identifikatorer
URN: urn:nbn:se:ri:diva-30030DOI: 10.1016/j.ijpharm.2017.04.041Scopus ID: 2-s2.0-85019091475OAI: oai:DiVA.org:ri-30030DiVA, id: diva2:1119649
Tillgänglig från: 2017-07-04 Skapad: 2017-07-04 Senast uppdaterad: 2019-07-02Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextScopus
Av organisationen
Kemi och material
I samma tidskrift
International Journal of Pharmaceutics
Kemiteknik

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 54 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
v. 2.35.8