Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Sensitive magnetic biodetection using magnetic multi-core nanoparticles and RCA coils
RISE - Research Institutes of Sweden, ICT, Acreo.
RISE - Research Institutes of Sweden, ICT, Acreo.ORCID-id: 0000-0002-6148-3574
RISE - Research Institutes of Sweden, ICT, Acreo.
RISE - Research Institutes of Sweden, ICT, Acreo.
Visa övriga samt affilieringar
2017 (Engelska)Ingår i: Journal of Magnetism and Magnetic Materials, ISSN 0304-8853, E-ISSN 1873-4766, Vol. 427, s. 14-18Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

We use functionalized iron oxide magnetic multi-core particles of 100 nm in size (hydrodynamic particle diameter) and AC susceptometry (ACS) methods to measure the binding reactions between the magnetic nanoparticles (MNPs) and bio-analyte products produced from DNA segments using the rolling circle amplification (RCA) method. We use sensitive induction detection techniques in order to measure the ACS response. The DNA is amplified via RCA to generate RCA coils with a specific size that is dependent on the amplification time. After about 75 min of amplification we obtain an average RCA coil diameter of about 1 µm. We determine a theoretical limit of detection (LOD) in the range of 11 attomole (corresponding to an analyte concentration of 55 fM for a sample volume of 200 µL) from the ACS dynamic response after the MNPs have bound to the RCA coils and the measured ACS readout noise. We also discuss further possible improvements of the LOD.

Ort, förlag, år, upplaga, sidor
2017. Vol. 427, s. 14-18
Nyckelord [en]
AC susceptometry, Biodetection, Differential induction coil, Magnetic multi-core particles, Magnetic nanoparticles, RCA coil, Magnetism, Nanoparticles, Differential induction, Magnetic nano-particles, Multi core, Nanomagnetics
Nationell ämneskategori
Naturvetenskap
Identifikatorer
URN: urn:nbn:se:ri:diva-29330DOI: 10.1016/j.jmmm.2016.10.041Scopus ID: 2-s2.0-85006097391OAI: oai:DiVA.org:ri-29330DiVA, id: diva2:1093942
Konferens
11th International Conference on the Scientific and Clinical Applications of Magnetic Carrier
Tillgänglig från: 2017-05-08 Skapad: 2017-05-08 Senast uppdaterad: 2019-06-27Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextScopus

Personposter BETA

Blomgren, JakobJohansson, Christer

Sök vidare i DiVA

Av författaren/redaktören
Blomgren, JakobJohansson, Christer
Av organisationen
Acreo
I samma tidskrift
Journal of Magnetism and Magnetic Materials
Naturvetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 201 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
v. 2.35.7