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Antimicrobial peptides: An emerging category of therapeutic agents
Promore Pharma AB, Sweden; University of Gothenburg, Sweden.
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.ORCID iD: 0000-0002-4270-8475
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science.
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik. University of Gothenburg, Sweden.ORCID iD: 0000-0002-3034-6745
2016 (English)In: Frontiers in Cellular and Infection Microbiology, E-ISSN 2235-2988, Vol. 6, no DEC, article id 194Article in journal (Refereed) Published
Abstract [en]

Antimicrobial peptides (AMPs), also known as host defense peptides, are short and generally positively charged peptides found in a wide variety of life forms from microorganisms to humans. Most AMPs have the ability to kill microbial pathogens directly, whereas others act indirectly by modulating the host defense systems. Against a background of rapidly increasing resistance development to conventional antibiotics all over the world, efforts to bring AMPs into clinical use are accelerating. Several AMPs are currently being evaluated in clinical trials as novel anti-infectives, but also as new pharmacological agents to modulate the immune response, promote wound healing, and prevent post-surgical adhesions. In this review, we provide an overview of the biological role, classification, and mode of action of AMPs, discuss the opportunities and challenges to develop these peptides for clinical applications, and review the innovative formulation strategies for application of AMPs.

Place, publisher, year, edition, pages
Frontiers Research Foundation , 2016. Vol. 6, no DEC, article id 194
Keywords [en]
AMP, antimicrobial peptide, anti-infectives, antibiotic resistance, therapeutic agents
National Category
Infectious Medicine Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:ri:diva-27767DOI: 10.3389/fcimb.2016.00194Scopus ID: 2-s2.0-85009823798OAI: oai:DiVA.org:ri-27767DiVA, id: diva2:1062568
Note

Published 27 December

Available from: 2017-01-06 Created: 2017-01-06 Last updated: 2023-05-22Bibliographically approved

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Håkansson, JoakimBjörn, Camilla

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