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3D bioprinting of carboxymethylated-periodate oxidized nanocellulose constructs for wound dressing applications
Swansea University, UK.
Swansea University, UK; Cardiff University, UK.
RISE., Innventia, PFI – Paper and Fiber Research Institute.ORCID-id: 0000-0002-6183-2017
Swansea University, UK.
Vise andre og tillknytning
2015 (engelsk)Inngår i: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, Vol. 2015, artikkel-id 925757Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Nanocellulose has a variety of advantages, which make the material most suitable for use in biomedical devices such as wound dressings. The material is strong, allows for production of transparent films, provides a moist wound healing environment, and can form elastic gels with bioresponsive characteristics. In this study, we explore the application of nanocellulose as a bioink for modifying film surfaces by a bioprinting process. Two different nanocelluloses were used, prepared with TEMPO mediated oxidation and a combination of carboxymethylation and periodate oxidation. The combination of carboxymethylation and periodate oxidation produced a homogeneous material with short nanofibrils, having widths <20 nm and lengths <200 nm. The small dimensions of the nanofibrils reduced the viscosity of the nanocellulose, thus yielding a material with good rheological properties for use as a bioink. The nanocellulose bioink was thus used for printing 3D porous structures, which is exemplified in this study. We also demonstrated that both nanocelluloses did not support bacterial growth, which is an interesting property of these novel materials.

sted, utgiver, år, opplag, sider
2015. Vol. 2015, artikkel-id 925757
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URN: urn:nbn:se:ri:diva-18941DOI: 10.1155/2015/925757PubMedID: 26090461Scopus ID: 2-s2.0-84930959572OAI: oai:DiVA.org:ri-18941DiVA, id: diva2:1040122
Tilgjengelig fra: 2016-10-26 Laget: 2016-10-26 Sist oppdatert: 2019-07-02bibliografisk kontrollert

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