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Translational study between structure and biological response of nanocellulose from wood and green algae
Uppsala University, Sweden.
Uppsala University, Sweden.
RISE., Innventia.
RISE., Innventia.
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2014 (Engelska)Ingår i: RSC Advances, E-ISSN 2046-2069, Vol. 4, nr 6, s. 2892-2903Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The influence of nanostructure on the cytocompatibility of cellulose films is analyzed providing insight into how physicochemical properties of surface modified microfibrillated cellulose (MFC) and Cladophora nanocellulose (CC) affect the materials cytocompatibility. CC is modified through TEMPO-mediated oxidation and glycidyltrimethylammonium chloride (EPTMAC) condensation to obtain anionic and cationic nanocellulose samples respectively, while anionic and cationic MFC samples are obtained by carboxymethylation and EPTMAC condensation respectively. Films of unmodified, anionic and cationic MFC and CC are prepared by vacuum filtration and characterized in terms of specific surface area, pore size distribution, degree of crystallinity, surface charge and water content. Human dermal fibroblasts are exposed to culture medium extracts of the films in an indirect contact cytotoxicity test. Moreover, cell adhesion and viability are evaluated in a direct contact assay and the effects of the physicochemical properties on cell behavior are discussed. In the indirect cytotoxicity test no toxic leachables are detected, evidencing that the CC and MFC materials are non-cytotoxic, independently of the chemical treatment that they have been subjected to. The direct contact tests show that carboxymethylated-MFC presents a more cytocompatible profile than unmodified and trimethylammonium-MFC. TEMPO-CC promotes fibroblast adhesion and presents cell viability comparable to the results obtained with the tissue culture material Thermanox. We hypothesize that the distinct aligned nanofiber structure present in the TEMPO-CC films is responsible for the improved cell adhesion. Thus, by controlling the surface properties of cellulose nanofibers, such as chemistry, charge, and orientation, cell adhesion properties can be promoted.

Ort, förlag, år, upplaga, sidor
2014. Vol. 4, nr 6, s. 2892-2903
Nationell ämneskategori
Organisk kemi Nanoteknik
Identifikatorer
URN: urn:nbn:se:ri:diva-9837DOI: 10.1039/c3ra45553jScopus ID: 2-s2.0-84890731330OAI: oai:DiVA.org:ri-9837DiVA, id: diva2:968623
Tillgänglig från: 2016-09-12 Skapad: 2016-09-12 Senast uppdaterad: 2022-09-15Bibliografiskt granskad

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Totalt: 34 träffar
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