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Healing of complement activating Ti implants compared with non-activating Ti in rat tibia
University of Gothenburg, Sweden.
University of Tokyo, Japan.
RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Medicinteknik.ORCID-id: 0000-0002-9442-7245
University of Gothenburg, Sweden.
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2012 (Engelska)Ingår i: Acta Biomaterialia, ISSN 1742-7061, E-ISSN 1878-7568, Vol. 8, nr 9, s. 3532-3540Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Recent studies have revealed that ozone ultraviolet (UVO) illumination of titanium (Ti) implants improves bone-implant anchorage by altering the physico-chemical and immune activating properties of the titanium dioxide (TiO2) layer. In the present rat tibia model, the authors compared the early events of inflammation and bone formation around UVO-treated Ti and complement activating immunoglobin g (IgG)-coated Ti. Machined Ti and machined Ti coated with a physical vapour-deposited Ti layer were used as references. Screw-shaped test and reference implants were implanted into rat tibia and harvested after 1, 7 and 28 days. Messenger RNA expression of implant adhered cells and peri-implant tissue ∼250 μm from the surface were subsequently analysed with regard to IL-1β, TNF-α, osteocalcin, cathepsin K, BMP-2 and PDGF. Separate implants were retrieved after 7 and 28 days for removal torque measurements, and histological staining and histomorphometric analysis of bone area and bone-to-implant contact. While enhanced expression of inflammatory markers, TNF-α and IL-1β, was observed on IgG-coated surfaces throughout the observation time, UVO-treated surfaces indicated a significantly lower early inflammatory response. In the early phases (1 and 7 days), the UVO-treated surfaces displayed a significantly higher expression of osteoblast markers BMP-2 and osteocalcin. In summary, complement activating Ti implants elicited a stronger inflammatory response than UVO-treated Ti, with low complement activation during the first week of healing. In spite of this, the UVO-treated Ti induced only marginally more bone growth outside the implants.

Ort, förlag, år, upplaga, sidor
2012. Vol. 8, nr 9, s. 3532-3540
Nyckelord [en]
Bone, Complement, Healing, In vivo, Titanium
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Naturvetenskap
Identifikatorer
URN: urn:nbn:se:ri:diva-6423DOI: 10.1016/j.actbio.2012.05.017Scopus ID: 2-s2.0-84864400610Lokalt ID: 23966OAI: oai:DiVA.org:ri-6423DiVA, id: diva2:964261
Tillgänglig från: 2016-09-08 Skapad: 2016-09-08 Senast uppdaterad: 2023-06-02Bibliografiskt granskad

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