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Lipid-based nanoformulations for peptide delivery
Inserm, France.
RISE., SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science.ORCID-id: 0000-0003-4742-1702
Inserm, France.
Inserm, France.
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2016 (Engelska)Ingår i: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 502, nr 1-2, s. 80-97Artikel, forskningsöversikt (Refereegranskat) Published
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Abstract [en]

Nanoformulations have attracted a lot of attention because of their size-dependent properties. Among the array of nanoformulations, lipid nanoformulations (LNFs) have evoked increasing interest because of the advantages of their high degree of biocompatibility and versatility. The performance of lipid nanoformulations is greatly influenced by their composition and structure. Therapeutic peptides represent a growing share of the pharmaceutical market. However, the main challenge for their development into commercial products is their inherent physicochemical and biological instability. Important peptides such as insulin, calcitonin and cyclosporin A have been incorporated into LNFs. The association or encapsulation of peptides within lipid-based carriers has shown to protect the labile molecules against enzymatic degradation. This review describes strategies used for the formulation of peptides and some methods used for the assessment of association efficiency. The advantages and drawbacks of such carriers are also described.

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Elsevier, 2016. Vol. 502, nr 1-2, s. 80-97
Nyckelord [en]
Drug delivery, Lipids, Nanoformulations, Peptides
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Annan kemi Fysikalisk kemi Farmaceutiska vetenskaper
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URN: urn:nbn:se:ri:diva-90DOI: 10.1016/j.ijpharm.2016.02.019Scopus ID: 2-s2.0-84959179307OAI: oai:DiVA.org:ri-90DiVA, id: diva2:930616
Tillgänglig från: 2016-05-24 Skapad: 2016-04-28 Senast uppdaterad: 2019-06-17Bibliografiskt granskad

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Boge, LukasBysell, Helena

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