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Biomechanical and histomorphometric evaluation of skin integration on titanium and PEEK implants with different surface treatments
Promimic AB, Sweden.
Promimic AB, Sweden.
RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning. University of Gothenburg, Sweden.ORCID-id: 0000-0002-4270-8475
RISE Research Institutes of Sweden, Material och produktion, Kemi och Tillämpad mekanik.ORCID-id: 0009-0004-4933-6629
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2022 (Engelska)Ingår i: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 33, nr 10, artikel-id 68Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Percutaneous implants are frequently affected by bacterial growth at the skin-implant interface. Integration between implant and surrounding skin is important to prevent bacteria from spreading to the underlying tissue. The standard method to evaluate skin-implant integration is by histomorphometry on samples which have been placed in tissue grown in vivo or ex vivo. In this study, a biomechanical method was developed and evaluated. The integration of implants into porcine skin was studied in an ex vivo model, where pig skin samples were cultivated in a nutrient solution. Cylindrical shaped implants, consisting of polyether ether ketone (PEEK) and titanium (Ti) with different surface treatments, were implanted in the skin tissue and the skin was grown in nutrient solution for 2 weeks. The implants were then extracted from the implantation site and the mechanical force during extraction was measured as a quantitative assessment of skin-implant integration. Implants from each group were also processed for histomorphometry and the degree of epidermal downgrowth (ED) and tissue to implant contact (TIC) was measured. A higher mean pullout force was observed for the PEEK implants compared to the Ti implants. Applying nanosized hydroxyapatite (HA) on Ti and PEEK increased the pullout force compared to uncoated controls, 24% for machined and 70% for blasted Ti, and 51% for machined PEEK. Treatment of Ti and PEEK with nanosized zirconium phosphate (ZrP) did not increase the pullout force. The histomorphometry analysis showed correlation between ED and pullout force, where the pullout force was inversely proportional to ED. For TIC, no significant differences were observed between the groups of same material (i.e. Ti, Ti+HA, Ti+ZrP, and PEEK, PEEK + HA, PEEK + ZrP), but it was significantly higher for PEEK compared to Ti. Scanning electron microscopy analysis was done on samples before and after the pullout tests, showing that the ZrP coating was unaffected by the 2 week ex vivo implantation and pullout procedure, no dissolution or detachment of the coating was observed. For the HA coating, a loss of coating was seen on approximately 5% of the total surface area of the implant. [Figure not available: see fulltext.] © 2022, The Author(s).

Ort, förlag, år, upplaga, sidor
Springer , 2022. Vol. 33, nr 10, artikel-id 68
Nyckelord [en]
Bacteria, Biocompatibility, Biomechanics, Coatings, Ethers, Integration, Ketones, Mammals, Nutrients, Scanning electron microscopy, Tissue, Titanium carbide, Bacterial growth, Ex-vivo, Histomorphometry, Implant interfaces, In-vivo, Nutrient solution, Pullout force, Skin implants, Titania, Zirconium phosphate, Hydroxyapatite, nanohydroxyapatite, nanomaterial, polyetheretherketone, titanium, unclassified drug, benzophenone derivative, ether derivative, ketone, macrogol, polymer, animal experiment, animal tissue, Article, bone tissue, coating (procedure), controlled study, dissolution, ex vivo study, force, implantation, morphometry, nonhuman, quantitative analysis, surface area, surface property, Yorkshire pig, animal, osseointegration, pig, tooth implant, Animals, Benzophenones, Dental Implants, Durapatite, Polyethylene Glycols, Polymers, Surface Properties, Swine
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Annan medicinsk bioteknologi
Identifikatorer
URN: urn:nbn:se:ri:diva-61212DOI: 10.1007/s10856-022-06687-yScopus ID: 2-s2.0-85139239686OAI: oai:DiVA.org:ri-61212DiVA, id: diva2:1715577
Anmärkning

Funding details: 214487; Funding details: Sahlgrenska Akademin; Funding text 1: Toponova AB, Halmstad, Sweden, is acknowledged for the interferometry measurements. Petra Hammarström Johansson at the Institute of Odontology, Sahlgrenska Academy, Gothenburg, is acknowledged for the histology processing. The study was partly financed by Region Västra Götaland FoU-card advanced (Dnr 214487); Funding text 2: Toponova AB, Halmstad, Sweden, is acknowledged for the interferometry measurements. Petra Hammarström Johansson at the Institute of Odontology, Sahlgrenska Academy, Gothenburg, is acknowledged for the histology processing. The study was partly financed by Region Västra Götaland FoU-card advanced (Dnr 214487)

Tillgänglig från: 2022-12-02 Skapad: 2022-12-02 Senast uppdaterad: 2024-06-20Bibliografiskt granskad

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Håkansson, JoakimAgrenius, KarinAndersson, ThereseStenlund, Patrik

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