Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Temperature and Heat Transfer Control During Freeze Drying. Effect of Vial Holders and Influence of Pressure
Lunds University, Sweden.
RISE Research Institutes of Sweden. Lunds University, Sweden.
Lunds University, Sweden.
Lunds University, Sweden.
Visa övriga samt affilieringar
2022 (Engelska)Ingår i: Pharmaceutical research, ISSN 0724-8741, E-ISSN 1573-904X, Vol. 39, s. 2597-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: A common issue of freeze drying is the inhomogeneity between samples, both in regards to water content and structure. The purpose of this study is to address this issue, and try to understand the cause of inhomogeneity in the heat transfer and sample temperature. Methods: The temperature and the heat transfer was measured using different setups, both with and without vial holders at various positions at different shelf temperature and chamber pressures. By comparing sublimation rate measurements (water sample) with temperature equilibrium measurements with a non-evaporating liquid (oil sample), the heat transfer contribution from radiation and conduction could be separated and investigated individually. Results: The oil sample temperature increases each time the pressure is decreased; the increase is highest at lower shelf temperatures. Using vial holder reduces the deviation between the samples but have limited effect on the temperature increase. The sublimation rate for water sample is pressure dependent and samples close to the walls have a higher sublimation rate than vials in the center. The sublimation rate increases slightly when using a vial holder but the deviation between vials becomes more random. Conclusions: The heat transfer consists of conduction through rectified vapor and radiation from surrounding walls, about 65–75% of the heat is transferred by conduction and 25–35% by radiation under normal operational conditions. As the vial holder is also influenced by the radiation, the vial inside the holder is indirectly affected by the surrounding radiation. © 2022, The Author(s).

Ort, förlag, år, upplaga, sidor
Springer , 2022. Vol. 39, s. 2597-
Nyckelord [en]
freeze-frying, heat transfer, radiation, sublimation rate, vial holder
Nationell ämneskategori
Annan elektroteknik och elektronik
Identifikatorer
URN: urn:nbn:se:ri:diva-60066DOI: 10.1007/s11095-022-03353-4Scopus ID: 2-s2.0-85135560525OAI: oai:DiVA.org:ri-60066DiVA, id: diva2:1694522
Anmärkning

 Funding details: Vetenskapsrådet, VR, 2018-04730; Funding text 1: Open access funding provided by Lund University. This research was financed by BioGaia AB and Competence Centre NextBioForm, funded by Vinnova Swedish Governmental Agency for Innovation and The Swedish Research Council under grant number 2018-04730.

Tillgänglig från: 2022-09-09 Skapad: 2022-09-09 Senast uppdaterad: 2023-07-06Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextScopus

Person

Millqvist-Fureby, Anna

Sök vidare i DiVA

Av författaren/redaktören
Millqvist-Fureby, Anna
Av organisationen
RISE Research Institutes of SwedenKemiska processer och läkemedel
I samma tidskrift
Pharmaceutical research
Annan elektroteknik och elektronik

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 16 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf