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Controlling osteoblast morphology and proliferation via surface micro-topographies of implant biomaterials
University of Freiburg, Germany.
University of Freiburg, Germany.
University of Freiburg, Germany.
University of Freiburg, Germany.
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2020 (Engelska)Ingår i: Scientific Reports, E-ISSN 2045-2322, Vol. 10, nr 1, artikel-id 12810Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Current research on surface modifications has yielded advanced implant biomaterials. Various implant surface modifications have been shown to be promising in improving bone target cell response, but more comprehensive studies whether certain implant surface modifications can directly target cell behavioural features such as morphogenesis and proliferation are needed. Here, we studied the response of primary alveolar bone cells on various implant surface modifications in terms of osteoblast morphology and proliferation in vitro. Analyses of surface modifications led to surface-related test parameters including the topographical parameters micro-roughness, texture aspect and surface enlargement as well as the physicochemical parameter surface wettability. We compared osteoblast morphology and proliferation towards the above-mentioned parameters and found that texture aspect and surface enlargement but not surface roughness or wettability exhibited significant impact on osteoblast morphology and proliferation. Detailed analysis revealed osteoblast proliferation as a function of cell morphology, substantiated by an osteoblast size- and morphology-dependent increase in mitotic activity. These findings show that implant surface topography controls cell behavioural morphology and subsequently cell proliferation, thereby opening the road for cell instructive biomaterials. © 2020, The Author(s).

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Nature Research , 2020. Vol. 10, nr 1, artikel-id 12810
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Naturvetenskap
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URN: urn:nbn:se:ri:diva-45605DOI: 10.1038/s41598-020-69685-6Scopus ID: 2-s2.0-85088815967OAI: oai:DiVA.org:ri-45605DiVA, id: diva2:1458214
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Funding details: 280741; Funding details: Seventh Framework Programme, FP7; Funding text 1: The authors express their gratitude to Yrgalem Abreha for her excellent technical assistance. This study has been performed within the LONGLIFE project and received funding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 280741. Open access funding provided by Projekt DEAL.

Tillgänglig från: 2020-08-14 Skapad: 2020-08-14 Senast uppdaterad: 2022-09-15Bibliografiskt granskad

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