Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Quantitative Grafting for Structure-Function Establishment: Thermoresponsive Poly(alkylene oxide) Graft Copolymers Based on Hyaluronic Acid and Carboxymethylcellulose
RISE - Research Institutes of Sweden, Material och produktion, IVF. Max Planck Institute of Colloids and Interfaces, Germany.ORCID-id: 0000-0002-7939-4684
Chalmers University of Technology, Sweden; Flinders University, Australia.
University of Gothenburg, Sweden.
Chalmers University of Technology, Sweden.
2019 (Engelska)Ingår i: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 20, nr 3, s. 1271-1280Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

A series of thermoresponsive graft copolymers, gelling at physiological conditions in aqueous solution and cell growth media, have been synthesized using quantitative coupling between a small set of amino-functionalized poly(alkylene oxide) copolymers (PAO) and the carboxylate of the biologically important polysaccharides (PSa) carboxymethylcellulose and the less reactive hyaluronate. Quantitative grafting enables the establishment of structure-function relationship which is imperative for controlling the properties of in situ gelling hydrogels. The EDC/NHS-mediated reaction was monitored using SEC-MALLS, which revealed that all PAOs were grafted onto the PSa backbone. Aqueous solutions of the graft copolymers were Newtonian fluids at room temperatures and formed reversible physical gels at elevated temperatures which were noncytotoxic toward chondrocytes. The established structure-function relationship was most clearly demonstrated by inspecting the thermogelling strength and the onset of thermogelling in a phase diagram. The onset of the thermogelling function could be controlled by the global PAO concentration, independent of graft ratio.

Ort, förlag, år, upplaga, sidor
2019. Vol. 20, nr 3, s. 1271-1280
Nationell ämneskategori
Naturvetenskap
Identifikatorer
URN: urn:nbn:se:ri:diva-37823DOI: 10.1021/acs.biomac.8b01692PubMedID: 30681838OAI: oai:DiVA.org:ri-37823DiVA, id: diva2:1292968
Anmärkning

The Swedish Research Council FORMAS (2016–61 and 2018–02284), Vinnova (2017–04693), and the foundation Bengt Lundqvist minne (Postdoctoral Grant, no grant number available) are acknowledged for funding.

Tillgänglig från: 2019-03-01 Skapad: 2019-03-01 Senast uppdaterad: 2019-07-01Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Andersson Trojer, Markus

Sök vidare i DiVA

Av författaren/redaktören
Andersson Trojer, Markus
Av organisationen
IVF
I samma tidskrift
Biomacromolecules
Naturvetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 4 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
v. 2.35.8