Alkali cation exchange have received significant attention throughout the years, primarily with respect to introducing compressive stresses into the surface layer and for tailoring the refractive index surface profile. In the present paper, we discuss the trends in the effective diffusion coefficients when exchanging Na+ for monovalent cations (K+, Cu+, Ag+, Rb+ and Cs+) in the surface of soda-lime-silicate float glass. The discussion is based on structural glass chemistry data.