Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Flexible and Biocompatible Antifouling Polyurethane Surfaces Incorporating Tethered Antimicrobial Peptides through Click Reactions
RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning. University of Gothenburg, Sweden.ORCID-id: 0000-0002-9377-8924
Amicoat A/S, Norway; UiT The Arctic University of Norway, Norway.
RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning.ORCID-id: 0000-0003-2821-4142
Amicoat A/S, Norway.
Vise andre og tillknytning
2024 (engelsk)Inngår i: Macromolecular Bioscience, ISSN 1616-5187, E-ISSN 1616-5195, Vol. 4, artikkel-id 2300425Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Efficient, simple antibacterial materials to combat implant-associated infections are much in demand. Herein, the development of polyurethanes, both cross-linked thermoset and flexible and versatile thermoplastic, suitable for “click on demand” attachment of antibacterial compounds enabled via incorporation of an alkyne-containing diol monomer in the polymer backbone, is described. By employing different polyolic polytetrahydrofurans, isocyanates, and chain extenders, a robust and flexible material comparable to commercial thermoplastic polyurethane is prepared. A series of short synthetic antimicrobial peptides are designed, synthesized, and covalently attached in a single coupling step to generate a homogenous coating. The lead material is shown to be biocompatible and does not display any toxicity against either mouse fibroblasts or reconstructed human epidermis according to ISO and OECD guidelines. The repelling performance of the peptide-coated materials is illustrated against colonization and biofilm formation by Staphylococcus aureus and Staphylococcus epidermidis on coated plastic films and finally, on coated commercial central venous catheters employing LIVE/DEAD staining, confocal laser scanning microscopy, and bacterial counts. This study presents the successful development of a versatile and scalable polyurethane with the potential for use in the medical field to reduce the impact of bacterial biofilms. 

sted, utgiver, år, opplag, sider
John Wiley and Sons Inc , 2024. Vol. 4, artikkel-id 2300425
Emneord [en]
Bacteria; Biocompatibility; Biofilms; Cell culture; Coated materials; Crosslinking; Peptides; Plastic coatings; Reinforced plastics; Anti-foulings; Antibacterial materials; Antimicrobial peptide; Biocompatible; Click chemistry; Click reaction; Flexible; Implant-associated infection; On demands; Simple++; Polyurethanes
HSV kategori
Identifikatorer
URN: urn:nbn:se:ri:diva-68814DOI: 10.1002/mabi.202300425Scopus ID: 2-s2.0-85178409798OAI: oai:DiVA.org:ri-68814DiVA, id: diva2:1825023
Merknad

This study was financed by Amicoat A/S. The authors are grateful for the analytical assistance from RISE scientists L. Brive, P. Borchardt, K. Johansson, and J. Somertune.

Tilgjengelig fra: 2024-01-08 Laget: 2024-01-08 Sist oppdatert: 2024-05-23bibliografisk kontrollert

Open Access i DiVA

fulltext(5554 kB)123 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 5554 kBChecksum SHA-512
2286ac90953af97f2f52819832350f1e3f9153cba62d8ee6b119c5985e74c636b575da4ea11e070af8c1749d512f3d1fb818eb8c8a682c18511cca2c110432f4
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstScopus

Person

Berglin, MattiasCaous, Josefin SethLyvén, BennySvenson, Johan

Søk i DiVA

Av forfatter/redaktør
Berglin, MattiasCaous, Josefin SethLyvén, BennySvenson, Johan
Av organisasjonen
I samme tidsskrift
Macromolecular Bioscience

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 124 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 285 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
v. 2.43.0