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Anti-colonization effect of au surfaces with self-assembled molecular monolayers functionalized with antimicrobial peptides on s. Epidermidis
Amicoat AS, Norway; Arctic University of Norway, Norway.
Amicoat AS, Norway: Arctic University of Norway, Norway.
Arctic University of Norway, Norway.
RISE Research Institutes of Sweden.ORCID-id: 0000-0002-4729-9359
Vise andre og tillknytning
2021 (engelsk)Inngår i: Antibiotics, ISSN 0066-4774, E-ISSN 2079-6382, Vol. 10, nr 12, artikkel-id 1516Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Medical devices with an effective anti-colonization surface are important tools for com-batting healthcare-associated infections. Here, we investigated the anti-colonization efficacy of antimicrobial peptides covalently attached to a gold model surface. The gold surface was modified by a self-assembled polyethylene glycol monolayer with an acetylene terminus. The peptides were covalently connected to the surface through a copper-catalyzed [3 + 2] azide-acetylene coupling (CuAAC). The anti-colonization efficacy of the surfaces varied as a function of the antimicrobial activity of the peptides, and very effective surfaces could be prepared with a 6 log unit reduction in bacterial colonization. © 2021 by the authors. 

sted, utgiver, år, opplag, sider
MDPI , 2021. Vol. 10, nr 12, artikkel-id 1516
Emneord [en]
Anti-colonization, Antifouling, Antimicrobial peptide, Antimicrobial surface, Certika, Self-assembled monolayer, ToF-SIMS imaging, acetylene, copper, dichloromethane, gold, macrogol, macrogol 200, macrogol 400, phenylalanine, polypeptide antibiotic agent, self assembled monolayer, tryptophan, antibiotic sensitivity, antimicrobial activity, Article, bacterial colonization, colony forming unit, column chromatography, drug synthesis, electrospray mass spectrometry, Escherichia coli, Gram negative bacterium, healthcare associated infection, high performance liquid chromatography, lipophilicity, minimum inhibitory concentration, nonhuman, proton nuclear magnetic resonance, Staphylococcus epidermidis, time of flight mass spectrometry
HSV kategori
Identifikatorer
URN: urn:nbn:se:ri:diva-57900DOI: 10.3390/antibiotics10121516Scopus ID: 2-s2.0-85121753149OAI: oai:DiVA.org:ri-57900DiVA, id: diva2:1626020
Merknad

 Funding details: Norges Forskningsråd, 283272; Funding text 1: This research was funded by Amicoat AS and the Research Council of Norway, grant number 283272.

Tilgjengelig fra: 2022-01-10 Laget: 2022-01-10 Sist oppdatert: 2023-05-25bibliografisk kontrollert

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