Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Oxygenated Nanocellulose - A Material Platform for Antibacterial Wound Dressing Devices
Oxy Solutions, Norway.
RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning.ORCID-id: 0009-0004-4933-6629
RISE Research Institutes of Sweden, Material och produktion, Metodik för produktframtagning.ORCID-id: 0000-0003-4592-5851
Vise andre og tillknytning
2021 (engelsk)Inngår i: ACS Applied Bio Materials, E-ISSN 2576-6422, Vol. 4, nr 10, s. 7554-7562Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Both carboxylated cellulose nanofibrils (CNF) and dissolved oxygen (DO) have been reported to possess antibacterial properties. However, the combination for use as wound dressings against biofilm infections in chronic wounds is less known. The present study reports the development of oxygenated CNF dispersions that exhibit strong antibacterial effect. Carboxylated CNF dispersions with different oxidation levels were oxygenated by the OXY BIO System and tested for antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus. The results reveal that the higher oxidation level of the CNFs, the better antibacterial effect. Scanning electron microscopy of bacterial biofilms revealed that a potential mechanism of action of the CNFs is the formation of a network surrounding and entrapping the bacteria. This effect is further potentiated by the oxygenation process. A CNF sample (concentration 0.6 wt %) that was oxygenated to a DO level of 46.4 mg/L demonstrated a strong antibacterial effect against S. aureus in vivo using a mouse model of surgical site infection. The oxygenated CNF dispersion reduced the bacterial survival by 71%, after 24 h treatment. The potent antibacterial effect indicates that oxygenated nanocellulose is a promising material for antibacterial wound dressings. © 2021 The Authors.

sted, utgiver, år, opplag, sider
American Chemical Society , 2021. Vol. 4, nr 10, s. 7554-7562
Emneord [en]
antibacterial properties, biofilm infections, hyperoxia, nanocellulose, topical dressings, wound healing, Biofilms, Dispersions, Dissolved oxygen, Scanning electron microscopy, Antibacterial effects, Antibacterials, Cellulose nanofibrils, Nano-cellulose, Topical dressing, Wound dressings, Bacteria, Diseases, Formation, Oxidation, Processes, Surgical Dressings, Survival
HSV kategori
Identifikatorer
URN: urn:nbn:se:ri:diva-56894DOI: 10.1021/acsabm.1c00819Scopus ID: 2-s2.0-85117321748OAI: oai:DiVA.org:ri-56894DiVA, id: diva2:1613524
Merknad

 Funding details: Norges Forskningsråd, 283895, 309178; Funding text 1: This work was partly funded by the MANUNET III program (Project No. MNET17/NMCS-1204) and Research Council of Norway Grant No. 283895, MedIn project (“New functionalized medical devices for surgical interventions in the pelvic cavity”, Grant No. 283895), and the OxyPol project (“Oxygenated biopolymers for biomedical applications”, Grant No. 309178).

Tilgjengelig fra: 2021-11-22 Laget: 2021-11-22 Sist oppdatert: 2023-11-21bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstScopus

Person

Agrenius, KarinPetronis, SarunasHåkansson, JoakimChinga-Carrasco, Gary

Søk i DiVA

Av forfatter/redaktør
Agrenius, KarinPetronis, SarunasHåkansson, JoakimChinga-Carrasco, Gary
Av organisasjonen
I samme tidsskrift
ACS Applied Bio Materials

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 42 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
v. 2.43.0