Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Controlling osteoblast morphology and proliferation via surface micro-topographies of implant biomaterials
University of Freiburg, Germany.
University of Freiburg, Germany.
University of Freiburg, Germany.
University of Freiburg, Germany.
Vise andre og tillknytning
2020 (engelsk)Inngår i: Scientific Reports, E-ISSN 2045-2322, Vol. 10, nr 1, artikkel-id 12810Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Current research on surface modifications has yielded advanced implant biomaterials. Various implant surface modifications have been shown to be promising in improving bone target cell response, but more comprehensive studies whether certain implant surface modifications can directly target cell behavioural features such as morphogenesis and proliferation are needed. Here, we studied the response of primary alveolar bone cells on various implant surface modifications in terms of osteoblast morphology and proliferation in vitro. Analyses of surface modifications led to surface-related test parameters including the topographical parameters micro-roughness, texture aspect and surface enlargement as well as the physicochemical parameter surface wettability. We compared osteoblast morphology and proliferation towards the above-mentioned parameters and found that texture aspect and surface enlargement but not surface roughness or wettability exhibited significant impact on osteoblast morphology and proliferation. Detailed analysis revealed osteoblast proliferation as a function of cell morphology, substantiated by an osteoblast size- and morphology-dependent increase in mitotic activity. These findings show that implant surface topography controls cell behavioural morphology and subsequently cell proliferation, thereby opening the road for cell instructive biomaterials. © 2020, The Author(s).

sted, utgiver, år, opplag, sider
Nature Research , 2020. Vol. 10, nr 1, artikkel-id 12810
HSV kategori
Identifikatorer
URN: urn:nbn:se:ri:diva-45605DOI: 10.1038/s41598-020-69685-6Scopus ID: 2-s2.0-85088815967OAI: oai:DiVA.org:ri-45605DiVA, id: diva2:1458214
Merknad

Funding details: 280741; Funding details: Seventh Framework Programme, FP7; Funding text 1: The authors express their gratitude to Yrgalem Abreha for her excellent technical assistance. This study has been performed within the LONGLIFE project and received funding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 280741. Open access funding provided by Projekt DEAL.

Tilgjengelig fra: 2020-08-14 Laget: 2020-08-14 Sist oppdatert: 2022-09-15bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstScopus

Person

Adolfsson, Erik

Søk i DiVA

Av forfatter/redaktør
Adolfsson, Erik
Av organisasjonen
I samme tidsskrift
Scientific Reports

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 25 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
v. 2.45.0