Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Biofilm formation on three different endotracheal tubes: a prospective clinical trial
Lund University, Sweden; Skåne University Hospital, Sweden.
Lund University, Sweden; Skåne University Hospital, Sweden.
Lund University, Sweden.
RISE Research Institutes of Sweden, Material och produktion, Kemi, biomaterial och textil.
Vise andre og tillknytning
2020 (engelsk)Inngår i: Critical Care, ISSN 1364-8535, E-ISSN 1466-609X, Vol. 24, nr 1Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Biofilm formation on endotracheal tubes (ETTs) is an early and frequent event in mechanically ventilated patients. The biofilm is believed to act as a reservoir for infecting microorganisms and thereby contribute to development and relapses of ventilator-associated pneumonia (VAP). Once a biofilm has formed on an ETT surface, it is difficult to eradicate. This clinical study aimed to compare biofilm formation on three widely used ETTs with different surface properties and to explore factors potentially predictive of biofilm formation. METHODS: We compared the grade of biofilm formation on ETTs made of uncoated polyvinyl chloride (PVC), silicone-coated PVC, and PVC coated with noble metals after > 24 h of mechanical ventilation in critically ill patients. The comparison was based on scanning electron microscopy of ETT surfaces, biofilm grading, surveillance and biofilm cultures, and occurrence of VAP. RESULTS: High-grade (score ≥ 7) biofilm formation on the ETTs was associated with development of VAP (OR 4.17 [95% CI 1.14-15.3], p = 0.031). Compared to uncoated PVC ETTs, the silicone-coated and noble-metal-coated PVC ETTs were independently associated with reduced high-grade biofilm formation (OR 0.18 [95% CI 0.06-0.59], p = 0.005, and OR 0.34 [95% CI 0.13-0.93], p = 0.036, respectively). No significant difference was observed between silicon-coated ETTs and noble-metal-coated ETTs (OR 0.54 [95% CI 0.17-1.65], p = 0.278). In 60% of the oropharyngeal cultures and 58% of the endotracheal cultures collected at intubation, the same microorganism was found in the ETT biofilm at extubation. In patients who developed VAP, the causative microbe remained in the biofilm in 56% of cases, despite appropriate antibiotic therapy. High-grade biofilm formation on ETTs was not predicted by either colonization with common VAP pathogens in surveillance cultures or duration of invasive ventilation. CONCLUSION: High-grade biofilm formation on ETTs was associated with development of VAP. Compared to the uncoated PVC ETTs, the silicone-coated and noble-metal-coated PVC ETTs were independently associated with reduced high-grade biofilm formation. Further research on methods to prevent, monitor, and manage biofilm occurrence is needed. TRIAL REGISTRATION: ClinicalTrials.gov NCT02284438 . Retrospectively registered on 21 October 2014.

sted, utgiver, år, opplag, sider
NLM (Medline) , 2020. Vol. 24, nr 1
Emneord [en]
Alloys, Biofilm, Critical illness, Intratracheal, Intubation, Pneumonia, Polyvinyl chloride, Silicones, Ventilator-associated
HSV kategori
Identifikatorer
URN: urn:nbn:se:ri:diva-45378DOI: 10.1186/s13054-020-03092-1Scopus ID: 2-s2.0-85087392955OAI: oai:DiVA.org:ri-45378DiVA, id: diva2:1455146
Merknad

Export Date: 15 July 2020; Article

Tilgjengelig fra: 2020-07-22 Laget: 2020-07-22 Sist oppdatert: 2020-12-01

Open Access i DiVA

fulltext(1138 kB)81 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 1138 kBChecksum SHA-512
1f9b8d96455e39b2c90361c41f7be5b7b97d240b34966486d577308e69f0050144ab856a5033632d878f49a78c52bb0ba7907a8dc538fe82ef93ccaf3776ac7d
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstScopus
Av organisasjonen
I samme tidsskrift
Critical Care

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 81 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 46 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
v. 2.41.0