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Development of a sensitive induction-based magnetic nanoparticle biodetection method
RISE - Research Institutes of Sweden, ICT, Acreo.ORCID-id: 0000-0002-6148-3574
RISE - Research Institutes of Sweden, ICT, Acreo.
RISE - Research Institutes of Sweden, ICT, Acreo.ORCID-id: 0000-0002-3618-9496
RISE - Research Institutes of Sweden, ICT, Acreo.ORCID-id: 0000-0003-0792-7039
Vise andre og tillknytning
2018 (engelsk)Inngår i: Nanomaterials, ISSN 2079-4991, Vol. 8, nr 11, artikkel-id 887Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

We developed a novel biodetection method for influenza virus based on AC magnetic susceptibility measurement techniques (the DynoMag induction technique) together with functionalized multi-core magnetic nanoparticles. The sample consisting of an incubated mixture of magnetic nanoparticles and rolling circle amplified DNA coils is injected into a tube by a peristaltic pump. The sample is moved as a plug to the two well-balanced detection coils and the dynamic magnetic moment in each position is read over a range of excitation frequencies. The time for making a complete frequency sweep over the relaxation peak is about 5 minutes (10 Hz–10 kHz with 20 data points). The obtained standard deviation of the magnetic signal at the relaxation frequency (around 100 Hz) is equal to about 10−5 (volume susceptibility SI units), which is in the same range obtained with the DynoMag system. The limit of detection with this method is found to be in the range of 1 pM.

sted, utgiver, år, opplag, sider
2018. Vol. 8, nr 11, artikkel-id 887
Emneord [en]
AC susceptibility, Brownian relaxation, Magnetic biosensing, Magnetic nanoparticles, Multi-core particles
HSV kategori
Identifikatorer
URN: urn:nbn:se:ri:diva-36359DOI: 10.3390/nano8110887Scopus ID: 2-s2.0-85056217345OAI: oai:DiVA.org:ri-36359DiVA, id: diva2:1266272
Tilgjengelig fra: 2018-11-27 Laget: 2018-11-27 Sist oppdatert: 2019-10-17bibliografisk kontrollert

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Blomgren, JakobIlver, DagJonasson, ChristianJohansson, Christer

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