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Isolation and synthesis of pulmonarin A and B, acetylcholinesterase inhibitors from the colonial ascidian Synoicum pulmonaria
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor.
Vise andre og tillknytning
2014 (engelsk)Inngår i: Journal of natural products (Print), ISSN 0163-3864, E-ISSN 1520-6025, Vol. 77, nr 2, s. 364-369Artikkel i tidsskrift (Fagfellevurdert)
Abstract [en]

Pulmonarins A and B are two new dibrominated marine acetylcholinesterase inhibitors that were isolated and characterized from the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast. The structures of natural pulmonarins A and B were tentatively elucidated by spectroscopic methods and later verified by comparison with synthetically prepared material. Both pulmonarins A and B displayed reversible, noncompetitive acetylcholinesterase inhibition comparable to several known natural acetylcholinesterase inhibitiors. Pulmonarin B was the strongest inhibitor, with an inhibition constant (Ki) of 20 μM. In addition to reversible, noncompetitive acetylcholinesterase inhibition, the compounds displayed weak antibacterial activity but no cytotoxicity or other investigated bioactivities.

sted, utgiver, år, opplag, sider
2014. Vol. 77, nr 2, s. 364-369
HSV kategori
Identifikatorer
URN: urn:nbn:se:ri:diva-27038DOI: 10.1021/np401002sOAI: oai:DiVA.org:ri-27038DiVA, id: diva2:1054042
Merknad
A3447Tilgjengelig fra: 2016-12-08 Laget: 2016-12-08 Sist oppdatert: 2017-11-29bibliografisk kontrollert

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