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Sustained release of ibuprofen from polyelectrolyte encapsulated mesoporous carriers
YKI – Ytkemiska institutet.
YKI – Ytkemiska institutet.
YKI – Ytkemiska institutet.
2009 (engelsk)Inngår i: Journal of Dispersion Science and Technology, ISSN 0193-2691, E-ISSN 1532-2351, Vol. 30, nr 6, s. 892-902Artikkel i tidsskrift (Fagfellevurdert)
Abstract [en]

Polyelectrolyte multilayers are receiving much attention due to their insolubility and due to structural responses induced in them by changes in solution properties such as, for example, temperature, pH or ionic strength. These characteristics make polyelectrolyte multilayers highly interesting in encapsulation technology and controlled delivery applications. However, producing dry, biocompatible formulations for storage of low molecular weight substances poses a challenge. One possibility is to make use of a well-defined mesoporous inorganic carrier material as host for the model substance (in our case ibuprofen). Control over release properties are enabled by polyelectrolyte encapsulation of the inorganic carrier. We built such multilayers through consecutive deposition of PAH and PSS on top of a first layer ofr PEI. These layers were adsorbed either in presence or absent of ibuprofen. The influence of long time storage, 2 years, of the samples was also investigated. The polyelectrolyte multilayer structure was investigated in detail by Dual Polarization Interferometry (DPI), and we use these data to interpret the measured release profiles.

sted, utgiver, år, opplag, sider
2009. Vol. 30, nr 6, s. 892-902
Emneord [en]
Dual polarization interferometry (DPI), ibuprofen, mesoporous particles, polyelectrolyte encapsulation, release properties
HSV kategori
Identifikatorer
URN: urn:nbn:se:ri:diva-26861DOI: 10.1080/01932690802644095OAI: oai:DiVA.org:ri-26861DiVA, id: diva2:1053864
Merknad
A1966Tilgjengelig fra: 2016-12-08 Laget: 2016-12-08 Sist oppdatert: 2017-11-29bibliografisk kontrollert

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