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Aqueous lubrication by fractionated salivary proteins: Synergistic interaction of mucin polymer brush with low molecular weight macromolecules
University of Queensland, Australia; Unilever, UK.
RISE, SP – Sveriges Tekniska Forskningsinstitut, SP Kemi Material och Ytor, Life Science. Unilever, UK.
Unilever, UK.
Unilever, UK.
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2015 (English)In: Tribology International, ISSN 0301-679X, E-ISSN 1879-2464, Vol. 89, p. 34-45Article in journal (Refereed) Published
Abstract [en]

The remarkable lubrication provided by saliva in the oral cavity is vital to human health and wellbeing. Yet, molecular mechanisms for saliva lubrication remain unclear. In this work we report a possible mechanism of synergistic interaction between salivary proteins. By isolating a number of salivary protein fractions, we identify major protein candidates that contribute to saliva lubrication. We discover that a key driver for low friction is a hydrated brush-like layer formed by glycosylated species, with an essential synergistic contribution coming from the low molecular weight components that facilitate spreading, adsorption and strengthening of the salivary film on hydrophobic substrates. Lessons may be learned from saliva for understanding other natural bio-aqueous lubrication systems and for the development of saliva mimics.

Place, publisher, year, edition, pages
2015. Vol. 89, p. 34-45
Keywords [en]
Saliva lubrication, Polymer brush, Atomic force microscopy, Soft-contact tribology
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:ri:diva-6837DOI: 10.1016/j.triboint.2014.12.025Scopus ID: 2-s2.0-84938395998Local ID: 23639OAI: oai:DiVA.org:ri-6837DiVA, id: diva2:964678
Available from: 2016-09-08 Created: 2016-09-08 Last updated: 2020-12-01Bibliographically approved

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