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Flexible Organic Electronic Ion Pump Fabricated Using Inkjet Printing and Microfabrication for Precision In Vitro Delivery of Bupivacaine
Linköping University, Sweden.
Linköping University, Sweden.
Karolinska Institute, Sweden.
Linköping University, Sweden.
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2023 (English)In: Advanced Healthcare Materials, ISSN 2192-2640, E-ISSN 2192-2659, Vol. 12, no 24, p. 2300550-Article in journal (Refereed) Published
Abstract [en]

The organic electronic ion pump (OEIP) is an on-demand electrophoretic drug delivery device, that via electronic to ionic signal conversion enables drug delivery without additional pressure or volume changes. The fundamental component of OEIPs is their polyelectrolyte membranes which are shaped into ionic channels that conduct and deliver ionic drugs, with high spatiotemporal resolution. The patterning of these membranes is essential in OEIP devices and is typically achieved using laborious microprocessing techniques. Here, the development of an inkjet printable formulation of polyelectrolyte is reported, based on a custom anionically functionalized hyperbranched polyglycerol (i-AHPG). This polyelectrolyte ink greatly simplifies the fabrication process and is used in the production of free-standing OEIPs on flexible polyimide (PI) substrates. Both i-AHPG and the OEIP devices are characterized, exhibiting favorable iontronic characteristics of charge selectivity and the ability to transport aromatic compounds. Further, the applicability of these technologies is demonstrated by the transport and delivery of the pharmaceutical compound bupivacaine to dorsal root ganglion cells with high spatial precision and effective nerve blocking, highlighting the applicability of these technologies for biomedical scenarios. © 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.

Place, publisher, year, edition, pages
John Wiley and Sons Inc , 2023. Vol. 12, no 24, p. 2300550-
Keywords [en]
bioelectronics, flexible devices, inkjet printing, polyelectrolytes, polyimide, Controlled drug delivery, Fabrication, Ink jet printing, Ions, Polyimides, Substrates, Targeted drug delivery, Bioelectronic, Bupivacaine, Flexible device, Flexible organic electronics, In-vitro, Ink-jet printing, Ion pumps, Micro-fabrication, On demands, Organic electronics
National Category
Materials Chemistry
Identifiers
URN: urn:nbn:se:ri:diva-65636DOI: 10.1002/adhm.202300550Scopus ID: 2-s2.0-85161982885OAI: oai:DiVA.org:ri-65636DiVA, id: diva2:1777489
Note

This work was supported by the Swedish Foundation for Strategic Research, the Knut and Alice Wallenberg Foundation, Vinnova, the Swedish Research Council, and the European Research Council (AdG 2018 Magnus Berggren, 834677). Additional support was provided by the Swedish Government Strategic Research Area in Materials Science on Advanced Functional Materials at Linköping University (Faculty Grant SFO‐Mat‐LiU no. 2009‐00971).

Available from: 2023-06-29 Created: 2023-06-29 Last updated: 2024-05-27Bibliographically approved

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