Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Biomechanical and histomorphometric evaluation of skin integration on titanium and PEEK implants with different surface treatments
Promimic AB, Sweden.
Promimic AB, Sweden.
RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology. University of Gothenburg, Sweden.ORCID iD: 0000-0002-4270-8475
RISE Research Institutes of Sweden, Materials and Production, Applied Mechanics.ORCID iD: 0009-0004-4933-6629
Show others and affiliations
2022 (English)In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 33, no 10, article id 68Article in journal (Refereed) Published
Abstract [en]

Percutaneous implants are frequently affected by bacterial growth at the skin-implant interface. Integration between implant and surrounding skin is important to prevent bacteria from spreading to the underlying tissue. The standard method to evaluate skin-implant integration is by histomorphometry on samples which have been placed in tissue grown in vivo or ex vivo. In this study, a biomechanical method was developed and evaluated. The integration of implants into porcine skin was studied in an ex vivo model, where pig skin samples were cultivated in a nutrient solution. Cylindrical shaped implants, consisting of polyether ether ketone (PEEK) and titanium (Ti) with different surface treatments, were implanted in the skin tissue and the skin was grown in nutrient solution for 2 weeks. The implants were then extracted from the implantation site and the mechanical force during extraction was measured as a quantitative assessment of skin-implant integration. Implants from each group were also processed for histomorphometry and the degree of epidermal downgrowth (ED) and tissue to implant contact (TIC) was measured. A higher mean pullout force was observed for the PEEK implants compared to the Ti implants. Applying nanosized hydroxyapatite (HA) on Ti and PEEK increased the pullout force compared to uncoated controls, 24% for machined and 70% for blasted Ti, and 51% for machined PEEK. Treatment of Ti and PEEK with nanosized zirconium phosphate (ZrP) did not increase the pullout force. The histomorphometry analysis showed correlation between ED and pullout force, where the pullout force was inversely proportional to ED. For TIC, no significant differences were observed between the groups of same material (i.e. Ti, Ti+HA, Ti+ZrP, and PEEK, PEEK + HA, PEEK + ZrP), but it was significantly higher for PEEK compared to Ti. Scanning electron microscopy analysis was done on samples before and after the pullout tests, showing that the ZrP coating was unaffected by the 2 week ex vivo implantation and pullout procedure, no dissolution or detachment of the coating was observed. For the HA coating, a loss of coating was seen on approximately 5% of the total surface area of the implant. [Figure not available: see fulltext.] © 2022, The Author(s).

Place, publisher, year, edition, pages
Springer , 2022. Vol. 33, no 10, article id 68
Keywords [en]
Bacteria, Biocompatibility, Biomechanics, Coatings, Ethers, Integration, Ketones, Mammals, Nutrients, Scanning electron microscopy, Tissue, Titanium carbide, Bacterial growth, Ex-vivo, Histomorphometry, Implant interfaces, In-vivo, Nutrient solution, Pullout force, Skin implants, Titania, Zirconium phosphate, Hydroxyapatite, nanohydroxyapatite, nanomaterial, polyetheretherketone, titanium, unclassified drug, benzophenone derivative, ether derivative, ketone, macrogol, polymer, animal experiment, animal tissue, Article, bone tissue, coating (procedure), controlled study, dissolution, ex vivo study, force, implantation, morphometry, nonhuman, quantitative analysis, surface area, surface property, Yorkshire pig, animal, osseointegration, pig, tooth implant, Animals, Benzophenones, Dental Implants, Durapatite, Polyethylene Glycols, Polymers, Surface Properties, Swine
National Category
Other Medical Biotechnology
Identifiers
URN: urn:nbn:se:ri:diva-61212DOI: 10.1007/s10856-022-06687-yScopus ID: 2-s2.0-85139239686OAI: oai:DiVA.org:ri-61212DiVA, id: diva2:1715577
Note

Funding details: 214487; Funding details: Sahlgrenska Akademin; Funding text 1: Toponova AB, Halmstad, Sweden, is acknowledged for the interferometry measurements. Petra Hammarström Johansson at the Institute of Odontology, Sahlgrenska Academy, Gothenburg, is acknowledged for the histology processing. The study was partly financed by Region Västra Götaland FoU-card advanced (Dnr 214487); Funding text 2: Toponova AB, Halmstad, Sweden, is acknowledged for the interferometry measurements. Petra Hammarström Johansson at the Institute of Odontology, Sahlgrenska Academy, Gothenburg, is acknowledged for the histology processing. The study was partly financed by Region Västra Götaland FoU-card advanced (Dnr 214487)

Available from: 2022-12-02 Created: 2022-12-02 Last updated: 2024-06-20Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopus

Authority records

Håkansson, JoakimAgrenius, KarinAndersson, ThereseStenlund, Patrik

Search in DiVA

By author/editor
Håkansson, JoakimAgrenius, KarinAndersson, ThereseStenlund, Patrik
By organisation
Product Realisation MethodologyApplied Mechanics
In the same journal
Journal of materials science. Materials in medicine
Other Medical Biotechnology

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 74 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf