Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Temperature and Heat Transfer Control During Freeze Drying. Effect of Vial Holders and Influence of Pressure
Lunds University, Sweden.
RISE Research Institutes of Sweden. Lunds University, Sweden.
Lunds University, Sweden.
Lunds University, Sweden.
Show others and affiliations
2022 (English)In: Pharmaceutical research, ISSN 0724-8741, E-ISSN 1573-904X, Vol. 39, p. 2597-Article in journal (Refereed) Published
Abstract [en]

Objective: A common issue of freeze drying is the inhomogeneity between samples, both in regards to water content and structure. The purpose of this study is to address this issue, and try to understand the cause of inhomogeneity in the heat transfer and sample temperature. Methods: The temperature and the heat transfer was measured using different setups, both with and without vial holders at various positions at different shelf temperature and chamber pressures. By comparing sublimation rate measurements (water sample) with temperature equilibrium measurements with a non-evaporating liquid (oil sample), the heat transfer contribution from radiation and conduction could be separated and investigated individually. Results: The oil sample temperature increases each time the pressure is decreased; the increase is highest at lower shelf temperatures. Using vial holder reduces the deviation between the samples but have limited effect on the temperature increase. The sublimation rate for water sample is pressure dependent and samples close to the walls have a higher sublimation rate than vials in the center. The sublimation rate increases slightly when using a vial holder but the deviation between vials becomes more random. Conclusions: The heat transfer consists of conduction through rectified vapor and radiation from surrounding walls, about 65–75% of the heat is transferred by conduction and 25–35% by radiation under normal operational conditions. As the vial holder is also influenced by the radiation, the vial inside the holder is indirectly affected by the surrounding radiation. © 2022, The Author(s).

Place, publisher, year, edition, pages
Springer , 2022. Vol. 39, p. 2597-
Keywords [en]
freeze-frying, heat transfer, radiation, sublimation rate, vial holder
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
URN: urn:nbn:se:ri:diva-60066DOI: 10.1007/s11095-022-03353-4Scopus ID: 2-s2.0-85135560525OAI: oai:DiVA.org:ri-60066DiVA, id: diva2:1694522
Note

 Funding details: Vetenskapsrådet, VR, 2018-04730; Funding text 1: Open access funding provided by Lund University. This research was financed by BioGaia AB and Competence Centre NextBioForm, funded by Vinnova Swedish Governmental Agency for Innovation and The Swedish Research Council under grant number 2018-04730.

Available from: 2022-09-09 Created: 2022-09-09 Last updated: 2023-07-06Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopus

Authority records

Millqvist-Fureby, Anna

Search in DiVA

By author/editor
Millqvist-Fureby, Anna
By organisation
RISE Research Institutes of SwedenChemical Process and Pharmaceutical Development
In the same journal
Pharmaceutical research
Other Electrical Engineering, Electronic Engineering, Information Engineering

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 16 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf