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Molecular Response to Nanopatterned Implants in the Human Jaw Bone
University of Gothenburg, Sweden.
Imam Abdulrahman Bin Faisal University, Saudi Arabia.
RISE Research Institutes of Sweden, Materials and Production, Product Realisation Methodology.ORCID iD: 0000-0003-4592-5851
University of Gothenburg, Sweden.
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2021 (English)In: ACS Biomaterials Science & Engineering, E-ISSN 2373-9878, Vol. 7, no 12, p. 5878-5889Article in journal (Refereed) Published
Abstract [en]

Implant surface modification by nanopatterning is an interesting route for enhancing osseointegration in humans. Herein, the mol. response to an intentional, controlled nanotopog. pattern superimposed on screw-shaped titanium implants is investigated in human bone. When clin. implants are installed, addnl. two mini-implants, one with a machined surface (M) and one with a machined surface superimposed with a hemispherical nanopattern (MN), are installed in the posterior maxilla. In the second-stage surgery, after 6-8 wk, the mini-implants are retrieved by unscrewing, and the implant-adherent cells are subjected to gene expression anal. using quant. polymerase chain reaction (qPCR). Compared to those adherent to the machined (M) implants, the cells adherent to the nanopatterned (MN) implants demonstrate significant upregulation (1.8- to 2-fold) of bone-related genes (RUNX2, ALP, and OC). No significant differences are observed in the expression of the analyzed inflammatory and remodeling genes. Correlation anal. reveals that older patient age is associated with increased expression of proinflammatory cytokines (TNF-α and MCP-1) on the machined implants and decreased expression of pro-osteogenic factor (BMP-2) on the nanopatterned implants. Controlled nanotopog., in the form of hemispherical 60 nm protrusions, promotes gene expressions related to early osteogenic differentiation and osteoblastic activity in implant-adherent cells in the human jaw bone.

Place, publisher, year, edition, pages
American Chemical Society , 2021. Vol. 7, no 12, p. 5878-5889
Keywords [en]
gene expression, human jaw, nanomedicine, nanotopography, osseointegration, osteogenic activities
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:ri:diva-57561DOI: 10.1021/acsbiomaterials.1c00861OAI: oai:DiVA.org:ri-57561DiVA, id: diva2:1625489
Available from: 2022-01-07 Created: 2022-01-07 Last updated: 2023-06-07Bibliographically approved

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