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Fortes Brollo, M. E., Domínguez-Bajo, A., Tabero, A., Domínguez-Arca, V., Gisbert, V., Prieto, G., . . . Morales, M. D. (2020). Combined Magnetoliposome Formation and Drug Loading in One Step for Efficient Alternating Current-Magnetic Field Remote-Controlled Drug Release.. ACS Applied Materials and Interfaces, 12(4), 4295-4307
Open this publication in new window or tab >>Combined Magnetoliposome Formation and Drug Loading in One Step for Efficient Alternating Current-Magnetic Field Remote-Controlled Drug Release.
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2020 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 12, no 4, p. 4295-4307Article in journal (Refereed) Published
Abstract [en]

We have developed a reproducible and facile one step strategy for the synthesis of doxorubicin loaded magnetoliposomes by using a thin-layer evaporation method. Liposomes of around 200 nm were made of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and iron oxide nanoparticles (NPs) with negative, positive, and hydrophobic surfaces that were incorporated outside, inside, or between the lipid bilayers, respectively. To characterize how NPs are incorporated in liposomes, advanced cryoTEM and atomic force microscope (AFM) techniques have been used. It was observed that only when the NPs are attached outside the liposomes, the membrane integrity is preserved (lipid melt transition shifts to 38.7 °C with high enthalpy 34.8 J/g) avoiding the leakage of the encapsulated drug while having good colloidal properties and the best heating efficiency under an alternating magnetic field (AMF). These magnetoliposomes were tested with two cancer cell lines, MDA-MB-231 and HeLa cells. First, 100% of cellular uptake was achieved with a high cell survival (above 80%), which is preserved (83%) for doxorubicin-loaded magnetoliposomes. Then, we demonstrate that doxorubicin release can be triggered by remote control, using a noninvasive external AMF for 1 h, leading to a cell survival reduction of 20%. Magnetic field conditions of 202 kHz and 30 mT seem to be enough to produce an effective heating to avoid drug degradation. In conclusion, these drug-loaded magnetoliposomes prepared in one step could be used for drug release on demand at a specific time and place, efficiently using an external AMF to reduce or even eliminate side effects.

Keywords
HeLa cells, MDA-MB-231 cells, doxorubicin, drug delivery carrier, magnetic hyperthermia, magnetoliposomes, superparamagnetic iron oxide nanoparticle
National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-43532 (URN)10.1021/acsami.9b20603 (DOI)31904927 (PubMedID)
Available from: 2020-01-31 Created: 2020-01-31 Last updated: 2020-01-31Bibliographically approved
Schier, P., Barton, C., Spassov, S., Johansson, C., Baumgarten, D., Kazakova, O., . . . Steinhoff, U. (2020). European Research on Magnetic Nanoparticles for Biomedical Applications: Standardisation Aspects. In: 21st Polish Conference on Biocybernetics and Biomedical Engineering, PCBBE 2019: . Paper presented at 25 September 2019 through 27 September 2019 (pp. 316-326). Springer Verlag
Open this publication in new window or tab >>European Research on Magnetic Nanoparticles for Biomedical Applications: Standardisation Aspects
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2020 (English)In: 21st Polish Conference on Biocybernetics and Biomedical Engineering, PCBBE 2019, Springer Verlag , 2020, p. 316-326Conference paper, Published paper (Refereed)
Abstract [en]

Magnetic nanoparticles have many applications in biomedicine and other technical areas. Despite their huge economic impact, there are no standardised procedures available to measure their basic magnetic properties. The International Organization for Standardization is working on a series of documents on the definition of characteristics of magnetic nanomaterials. We review previous and ongoing European research projects on characteristics of magnetic nanoparticles and present results of an online survey among European researchers.

Place, publisher, year, edition, pages
Springer Verlag, 2020
Keywords
European research, Magnetic nanoparticles, Standardisation, Biocybernetics, Biomedical engineering, Biophysics, Magnetic materials, Medical applications, Nanoparticles, Standardization, Biomedical applications, Economic impacts, European research project, International organization for standardizations, Magnetic nano-particles, Magnetic nanomaterials, Online surveys, Nanomagnetics
National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-43430 (URN)10.1007/978-3-030-29885-2_29 (DOI)2-s2.0-85072827876 (Scopus ID)9783030298845 (ISBN)
Conference
25 September 2019 through 27 September 2019
Note

Conference code: 230999; Export Date: 30 January 2020; Conference Paper; Funding details: 16NRM04; Funding text 1: This work was supported by the EMPIR program co-financed by the Participating States and from the European Union?s Horizon 2020 research and innovation program, grant no. 16NRM04 ?MagNaStand?.

Available from: 2020-01-31 Created: 2020-01-31 Last updated: 2020-01-31Bibliographically approved
Sepehri, S., Agnarsson, B., Torre, T., Schneiderman, J., Blomgren, J., Jesorka, A., . . . Kalaboukhov, A. (2019). Characterization of Binding of Magnetic Nanoparticles to Rolling Circle Amplification Products by Turn-On Magnetic Assay. Biosensors, 9(3)
Open this publication in new window or tab >>Characterization of Binding of Magnetic Nanoparticles to Rolling Circle Amplification Products by Turn-On Magnetic Assay
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2019 (English)In: Biosensors, ISSN 2079-6374, Vol. 9, no 3Article in journal (Refereed) Published
Abstract [en]

The specific binding of oligonucleotide-tagged 100 nm magnetic nanoparticles (MNPs) to rolling circle products (RCPs) is investigated using our newly developed differential homogenous magnetic assay (DHMA). The DHMA measures ac magnetic susceptibility from a test and a control samples simultaneously and eliminates magnetic background signal. Therefore, the DHMA can reveal details of binding kinetics of magnetic nanoparticles at very low concentrations of RCPs. From the analysis of the imaginary part of the DHMA signal, we find that smaller MNPs in the particle ensemble bind first to the RCPs. When the RCP concentration increases, we observe the formation of agglomerates, which leads to lower number of MNPs per RCP at higher concentrations of RCPs. The results thus indicate that a full frequency range of ac susceptibility observation is necessary to detect low concentrations of target RCPs and a long amplification time is not required as it does not significantly increase the number of MNPs per RCP. The findings are critical for understanding the underlying microscopic binding process for improving the assay performance. They furthermore suggest DHMA is a powerful technique for dynamically characterizing the binding interactions between MNPs and biomolecules in fluid volumes.

Place, publisher, year, edition, pages
NLM (Medline), 2019
Keywords
binding kinetics, bioassay, differential homogenous magnetic assay, immobilization, magnetic nanoparticle, rolling circle amplification product
National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-39975 (URN)10.3390/bios9030109 (DOI)s2.0-85072380802 (Scopus ID)
Available from: 2019-10-10 Created: 2019-10-10 Last updated: 2019-10-10Bibliographically approved
Riordan, E., Blomgren, J., Jonasson, C., Ahrentorp, F., Johansson, C., Margineda, D., . . . Giblin, S. R. (2019). Design and implementation of a low temperature, inductance based high frequency alternating current susceptometer.. Paper presented at 2019/08/08. Review of Scientific Instruments, 90(7)
Open this publication in new window or tab >>Design and implementation of a low temperature, inductance based high frequency alternating current susceptometer.
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2019 (English)In: Review of Scientific Instruments, Vol. 90, no 7Article in journal (Refereed) Published
Abstract [en]

We report on the implementation of an induction based, low temperature, high frequency ac susceptometer capable of measuring at frequencies up to 3.5 MHz and at temperatures between 2 K and 300 K. Careful balancing of the detection coils and calibration allow a sample magnetic moment resolution of 5 × 10−10 Am2 at 1 MHz. We discuss the design and characterization of the susceptometer and explain the calibration process. We also include some example measurements on the spin ice material CdEr2S4 and iron oxide based nanoparticles to illustrate functionality.

National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-39702 (URN)10.1063/1.5074154 (DOI)2-s2.0-85070086254 (Scopus ID)
Conference
2019/08/08
Available from: 2019-08-08 Created: 2019-08-08 Last updated: 2019-10-17Bibliographically approved
Baresel, C., Schaller, V., Jonasson, C., Johansson, C., Bordes, R., Chauhan, V., . . . Welling, S. (2019). Functionalized magnetic particles for water treatment. Heliyon, 5(8), Article ID e02325.
Open this publication in new window or tab >>Functionalized magnetic particles for water treatment
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2019 (English)In: Heliyon, ISSN 2405-8440, Vol. 5, no 8, article id e02325Article in journal (Refereed) Published
Abstract [en]

In this study, we have taken the concept of water treatment by functionalized magnetic particles one step forward by integrating the technology into a complete proof of concept, which included the preparation of surface modified beads, their use as highly selective absorbents for heavy metals ions (Zinc, Nickel), and their performance in terms of magnetic separation. The separation characteristics were studied both through experiments and by simulations. The data gathered from these experimental works enabled the elaboration of various scenarios for Life Cycle Analysis (LCA). The LCA showed that the environmental impact of the system is highly dependent on the recovery rate of the magnetic particles. The absolute impact on climate change varied significantly among the scenarios studied and the recovery rates. The results support the hypothesis that chelation specificity, magnetic separation and bead recovery should be optimized to specific targets and applications. 

Place, publisher, year, edition, pages
Elsevier Ltd, 2019
Keywords
Chemical engineering, Environmental science, Life cycle assessment, Magnetic particle, Materials chemistry, Nanotechnology, Pollutant, Water treatment
National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-39844 (URN)10.1016/j.heliyon.2019.e02325 (DOI)2-s2.0-85070906522 (Scopus ID)
Note

This work was supported by VINNOVA , the Swedish Governmental Agency for Innovation, within the call Innovationer för ett hållbart samhälle: miljö och transport.

Available from: 2019-10-01 Created: 2019-10-01 Last updated: 2019-10-17Bibliographically approved
Sepehri, S., Zardán Gómez De La Torre, T., Schneiderman, J. F., Blomgren, J., Jesorka, A., Johansson, C., . . . Kalaboukhov, A. (2019). Homogeneous Differential Magnetic Assay. ACS Sensors, 4(9), 2381-8
Open this publication in new window or tab >>Homogeneous Differential Magnetic Assay
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2019 (English)In: ACS Sensors, ISSN 2379-3694, Vol. 4, no 9, p. 2381-8Article in journal (Refereed) Published
Abstract [en]

Assays are widely used for detection of various targets, including pathogens, drugs, and toxins. Homogeneous assays are promising for the realization of point-of-care diagnostics as they do not require separation, immobilization, or washing steps. For low concentrations of target molecules, the speed and sensitivity of homogeneous assays have hitherto been limited by slow binding kinetics, time-consuming amplification steps, and the presence of a high background signal. Here, we present a homogeneous differential magnetic assay that utilizes a differential magnetic readout that eliminates previous limitations of homogeneous assays. The assay uses a gradiometer sensor configuration combined with precise microfluidic sample handling. This enables simultaneous differential measurement of a positive test sample containing a synthesized Vibrio cholerae target and a negative control sample, which reduces the background signal and increases the readout speed. Very low concentrations of targets down to femtomolar levels are thus detectable without any additional amplification of the number of targets. Our homogeneous differential magnetic assay method opens new possibilities for rapid and highly sensitive diagnostics at the point of care. 

Place, publisher, year, edition, pages
American Chemical Society, 2019
Keywords
binding kinetics, Brownian relaxation, homogeneous differential magnetic assay, magnetic nanoparticle, rolling circle amplification, volumetric detection, Amplification, Molecules, Nanoparticles, Brownian relaxations, Magnetic nano-particles, Rolling circle amplifications, Nanomagnetics
National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-39981 (URN)10.1021/acssensors.9b00969 (DOI)
Note

Funding details: Vetenskapsrådet, VR, 2015-03640; Funding details: Stiftelsen för Strategisk Forskning, SSF; Funding details: Stiftelsen för Strategisk Forskning, SSF, SBE13-0125; Funding details: Knut och Alice Wallenbergs Stiftelse; Funding text 1: S.S., J.F.S, A.K., and D.W. conceived and designed the experiments. S.S. conducted the experiments and analyzed the data. T.Z.G.d.l.T. contributed with the biochemical processes. A.J. helped with the fabrication of the microfluidics. J.B. performed reference ac susceptibility measurements and contributed in the discussion of the initial results. C.J. contributed in the discussion of the results and analysis. S.S. and A.K. drafted the manuscript. All authors reviewed the manuscript and provided comments. This work was supported through the Swedish Foundation for Strategic Research (SSF) Grant “FLU-ID” No. SBE13-0125, the Swedish Research Council Grant 2015-03640, the Knut and Alice Wallenberg Foundation, and the Swedish Infrastructure for Micro- and Nanofabrication–Myfab. The authors declare the following competing financial interest(s): S.S., A.K., and D.W. are co-inventors of a patent filed on the subject of this work. The other authors declare no competing interests.

Available from: 2019-10-09 Created: 2019-10-09 Last updated: 2020-01-23Bibliographically approved
Rusu, C., Krozer, A., Johansson, C., Ahrentorp, F., Pettersson, T., Jonasson, C., . . . Montagnoli, A. (2019). Miniaturized wireless water content and conductivity soil sensor system. Computers and Electronics in Agriculture, 167, Article ID 105076.
Open this publication in new window or tab >>Miniaturized wireless water content and conductivity soil sensor system
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2019 (English)In: Computers and Electronics in Agriculture, ISSN 0168-1699, E-ISSN 1872-7107, Vol. 167, article id 105076Article in journal (Refereed) Published
Abstract [en]

Obtaining more data for the research/studies of plants growing may be easier realized when suitable non-destructive detection methods are available. We are here presenting the development of a miniaturised, low-power, real-time, multi-parameter and cost-effective sensor for measurements in mini plugs (growth of seedling). The detection technique is based on measurement of electrical impedance at two frequencies for sensing two soil parameters, water content and water conductivity (dependent on e.g. total ions concentration). Electrical models were developed and comply with data at two frequencies. An easy and efficient calibration method for the sensor is established by using known liquids’ properties instead of various soil types. The measurements show a good correlation between the sensor's readings and the traditional soil testing. This soil sensor can easily send data wirelessly allowing for spot checks of substrate moisture levels throughout a greenhouse/field, and/or enable sensors to be buried inside the soil/substrate for long-term consecutive measurements.

Place, publisher, year, edition, pages
Elsevier B.V., 2019
Keywords
Easy calibration soil sensor, Miniaturised soil sensor, Multi-parameter electrical impedance, Soil water conductivity, Soil water content, Calibration, Cost effectiveness, Electric impedance, Electric impedance measurement, Parameter estimation, Soil moisture, Soil testing, Calibration method, Consecutive measurements, Cost-effective sensors, Electrical impedance, Nondestructive detection, Soil sensors, Soil water conductivities, Soil surveys
National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-40919 (URN)10.1016/j.compag.2019.105076 (DOI)2-s2.0-85075369301 (Scopus ID)
Note

Funding details: 308313, 783221; Funding text 1: This work is partially funded by EU-FP7-ENV grant Zephyr – Zero-impact innovative technology in forest plant production (grant agreement No 308313 ) and by ECSEL JU grant AFarCloud – Aggregate Farming in the Cloud (grant agreement No 783221 ).

Available from: 2019-12-10 Created: 2019-12-10 Last updated: 2019-12-10Bibliographically approved
Jonasson, C., Schaller, V., Zeng, L., Olsson, E., Frandsen, C., Castro, A., . . . Johansson, C. (2019). Modelling the effect of different core sizes and magnetic interactions inside magnetic nanoparticles on hyperthermia performance. Journal of Magnetism and Magnetic Materials, 477, 198-202
Open this publication in new window or tab >>Modelling the effect of different core sizes and magnetic interactions inside magnetic nanoparticles on hyperthermia performance
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2019 (English)In: Journal of Magnetism and Magnetic Materials, ISSN 0304-8853, E-ISSN 1873-4766, Vol. 477, p. 198-202Article in journal (Refereed) Published
Abstract [en]

We present experimental intrinsic loss power (ILP) values, measured at an excitation frequency of 1 MHz and at relatively low field amplitudes of 3.4 to 9.9 kA/m, as a function of the mean core diameter, for selected magnetic nanoparticle (MNP). The mean core sizes ranged from ca. 8 nm to 31 nm. Transmission electron microscopy indicated that those with smaller core sizes (less than ca. 22 nm) were single-core MNPs, while those with larger core sizes (ca. 29 nm to 31 nm) were multi-core MNPs. The ILP data showed a peak at ca. 20 nm. We show here that this behaviour correlates well with the predicted ILP values obtained using either a non-interacting Debye model, or via dynamic Monte-Carlo simulations, the latter including core-core magnetic interactions for the multi-core particles. This alignment of the models is a consequence of the low field amplitudes used. We also present interesting results showing that the core-core interactions affect the ILP value differently depending on the mean core size.

Keywords
magnetic nanoparticles, magnetic interactions, magnetic relaxation, Monte-Carlo simulations, multi-core particles, single-core particles
National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-36361 (URN)10.1016/j.jmmm.2018.09.117 (DOI)2-s2.0-85060279115 (Scopus ID)
Available from: 2018-11-27 Created: 2018-11-27 Last updated: 2019-10-17Bibliographically approved
Sriviriyakul, T., Bogren, S., Schaller, V., Jonasson, C., Blomgren, J., Ahrentorp, F., . . . Johansson, C. (2019). Nanorheological studies of xanthan/water solutions using magnetic nanoparticles. Journal of Magnetism and Magnetic Materials, 473, 268-271
Open this publication in new window or tab >>Nanorheological studies of xanthan/water solutions using magnetic nanoparticles
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2019 (English)In: Journal of Magnetism and Magnetic Materials, ISSN 0304-8853, E-ISSN 1873-4766, Vol. 473, p. 268-271Article in journal (Refereed) Published
Abstract [en]

We show results of nanorheological studies of different concentrations of xanthan (non-Newtonian fluid) in water using magnetic nanoparticles (MNPs) together with the AC susceptibility (ACS) vs frequency method. For comparison we also show the ACS response for different concentrations of glycerol in water (Newtonian fluid). The ACS response is measured, and the data is modelled using dynamic magnetic models and different viscoelastic models. We study the ACS response (in-phase and out-of-phase ACS components) at different concentrations of xanthan in water (up to 1 wt% xanthan) and with a constant concentration of MNPs. We use MNP systems that show Brownian relaxation (sensitive to changes in the environmental properties around the MNPs). ACS measurements are performed using the DynoMag system. The Brownian relaxation of the MNP system peak is shifting down in frequency and the ACS response is broadening and decreases due to changes in the viscoelastic properties around the MNPs in the xanthan solution. The viscosity and the storage moduli are determined at each excitation frequency and compared with traditional macroscopic small amplitude oscillatory shear rheological measurements. The results from the traditional rheological and nanorheological measurements correlate well at higher xanthan concentration.

Place, publisher, year, edition, pages
Elsevier B.V., 2019
Keywords
AC susceptibility, Brownian relaxation, Glycerol, Magnetic multi-core nanoparticles, Nanorheological measurements, Xanthan, Brownian movement, Digital storage, Magnetic susceptibility, Nanoparticles, Non Newtonian flow, Non Newtonian liquids, Rheology, Viscoelasticity, Ac susceptibility (ACS), Brownian relaxations, Magnetic nano-particles, Magnetic nanoparti cles (MNPs), Multi core, Viscoelastic properties, Nanomagnetics
National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-35560 (URN)10.1016/j.jmmm.2018.09.103 (DOI)2-s2.0-85055085870 (Scopus ID)
Note

The authors acknowledge Josefine Mosser for assistance with experimental work. This project receives funding from The Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning ( FORMAS ) under grant number 2016-00253 .

Available from: 2018-11-06 Created: 2018-11-06 Last updated: 2019-10-17Bibliographically approved
Elmquist, L., Carlsson, R. & Johansson, C. (2018). Cast iron components with intelligence. In: : . Paper presented at Mater. Sci. Forum. 4 September 2017 through 7 September 2017 (pp. 512-519). , 925
Open this publication in new window or tab >>Cast iron components with intelligence
2018 (English)Conference paper, Published paper (Refereed)
Abstract [en]

The paper describes a project with the aim to develop communicating and functional cast iron components in smart systems. The concept is based on sensors integrated into cast iron components; this will influence not only the component but also the casting process. Among the technical challenges is how to choose a sensor solution that cost-efficiently and with minimal environmental impact can be integrated into the component during the casting process, and especially without being damaged during mold filling and the high pouring temperature. Another challenge is how the iron will interact and interfere with sensor signals and whether an insulating intermediate material is needed or not. Integrating the sensors into the casting makes sensors a natural part of the component, which in turn can lead to more resource efficient designs, increased value added for the casting sector, and a general access to different possibilities of digitalization. The integrated sensors can be used for effective control and monitoring of components when in service and give information about for example how the component is used and what conditions it is exposed to. In other words, the component can tell when maintenance is needed or in worst cases, indicate that something is wrong before a failure will happen. Important measurands can e.g. be elongation, shear, temperature and vibration. Different combinations of sensor materials and insulating materials and their interaction with the cast iron have been investigated. It is shown how the interaction at the interface affects the microstructure and consequently the properties of the cast iron. In the case of insulating materials it is e.g. shown how air gaps are formed and in the case of sensor materials it is shown how a diffusion zone is formed and how this zone depends on the sensor material. How this diffusion zone affects the microstructure is discussed.

Keywords
Cast iron, Digitalized castings, Integrated sensors, Intelligent cast components, Intelligent castings, Interfacial phenomena, Environmental impact, Insulating materials, Insulation, Microstructure, Molds, Cast components, Control and monitoring, Intermediate materials, Pouring temperatures, Technical challenges, Without being damaged
National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-34469 (URN)10.4028/www.scientific.net/MSF.925.512 (DOI)2-s2.0-85050011551 (Scopus ID)9783035710557 (ISBN)
Conference
Mater. Sci. Forum. 4 September 2017 through 7 September 2017
Note

Funding details: VINNOVA;

Available from: 2018-08-09 Created: 2018-08-09 Last updated: 2019-06-27Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-6662-8023

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