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Publications (10 of 87) Show all publications
Lindblom, M., Patzauer, M., Vogt, U., Wilbur, S., Yazd, N. S., Hey Tow, K., . . . Ebenhag, S.-C. (2023). Flexible Liquid-Filled Scintillating Fibers for X-Ray Detection. In: 2023 IEEE SENSORS: . Paper presented at 2023 IEEE SENSORS.29 October 2023 - 01 November 2023. Vienna, Austria.. Institute of Electrical and Electronics Engineers (IEEE)
Open this publication in new window or tab >>Flexible Liquid-Filled Scintillating Fibers for X-Ray Detection
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2023 (English)In: 2023 IEEE SENSORS, Institute of Electrical and Electronics Engineers (IEEE), 2023Conference paper, Published paper (Refereed)
Abstract [en]

We present the design and fabrication of flexible, liquid-filled scintillating fibers for X-ray detection made from silica fibers and silica capillaries. The scintillating fibers were characterized using ultraviolet light exposure and we also performed an experiment demonstrating X-ray detection.

Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers (IEEE), 2023
National Category
Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
urn:nbn:se:ri:diva-68522 (URN)10.1109/SENSORS56945.2023.10325072 (DOI)
Conference
2023 IEEE SENSORS.29 October 2023 - 01 November 2023. Vienna, Austria.
Note

This project has received funding from the European Union's Horizon 2020 Research and Innovation Program under Grant Agreement No. 899634.

Available from: 2023-12-13 Created: 2023-12-13 Last updated: 2023-12-27Bibliographically approved
Kumar, T., Harish, A. V., Etcheverry, S., Margulis, W., Laurell, F. & Russom, A. (2023). Lab-in-a-fiber-based integrated particle separation and counting. Lab on a Chip, 23, 2286
Open this publication in new window or tab >>Lab-in-a-fiber-based integrated particle separation and counting
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2023 (English)In: Lab on a Chip, ISSN 1473-0197, E-ISSN 1473-0189, Vol. 23, p. 2286-Article in journal (Refereed) Published
Abstract [en]

An all-fiber integrated device capable of separating and counting particles is presented. A sequence of silica fiber capillaries with various diameters and longitudinal cavities are used to fabricate the component for size-based elasto-inertial passive separation of particles followed by detection in an uninterrupted continuous flow. Experimentally, fluorescent particles of 1 μm and 10 μm sizes are mixed in a visco-elastic fluid and fed into the all-fiber separation component. The particles are sheathed by an elasticity enhancer (PEO - polyethylene oxide) to the side walls. Larger 10 μm particles migrate to the center of the silica capillary due to the combined inertial lift force and elastic force, while the smaller 1 μm particles are unaffected, and exit from a side capillary. A separation efficiency of 100% for the 10 μm and 97% for the 1 μm particles is achieved at a total flow rate of 50 μL min−1. To the best of our knowledge, this is the first time effective inertial-based separation has been demonstrated in circular cross-section microchannels. In the following step, the separated 10 μm particles are routed through another all-fiber component for counting and a counting throughput of ∼1400 particles per min is demonstrated. We anticipate the ability to combine high throughput separation and precise 3D control of particle position for ease of counting will aid in the development of advanced microflow cytometers capable of particle separation and quantification for various biomedical applications. 

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2023
Keywords
Fibers, Medical applications, Particle separators, Silica, A.Fibres, All fiber, Continuous-flow, Fibre separation, Fluorescent particle, Integrated device, Particle counting, Particle separation, Silica fibers, Visco-elastic fluid, Polyethylene oxides
National Category
Subatomic Physics
Identifiers
urn:nbn:se:ri:diva-64396 (URN)10.1039/d2lc01175a (DOI)2-s2.0-85153253799 (Scopus ID)
Note

Funding details: Office of Naval Research Global, ONRG, N62909-20-1-2033; Funding details: Knut och Alice Wallenbergs Stiftelse, KAW 2016-0104; Funding details: Vetenskapsrådet, VR, VR 2021-05861; Funding text 1: This work was supported with funds provided by Office of Naval Research Global (N62909-20-1-2033), Swedish Research Council (VR 2021-05861) and Knut and Alice Wallenberg Foundation (KAW 2016-0104).

Available from: 2023-05-03 Created: 2023-05-03 Last updated: 2023-07-07Bibliographically approved
Parker, H., Sengupta, S., Harish, A., Soares, R., Joensson, H., Margulis, W., . . . Laurell, F. (2022). A Lab-in-a-Fiber optofluidic device using droplet microfluidics and laser-induced fluorescence for virus detection. Scientific Reports, 12(1), Article ID 3539.
Open this publication in new window or tab >>A Lab-in-a-Fiber optofluidic device using droplet microfluidics and laser-induced fluorescence for virus detection
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2022 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 12, no 1, article id 3539Article in journal (Refereed) Published
Abstract [en]

Microfluidics has emerged rapidly over the past 20 years and has been investigated for a variety of applications from life sciences to environmental monitoring. Although continuous-flow microfluidics is ubiquitous, segmented-flow or droplet microfluidics offers several attractive features. Droplets can be independently manipulated and analyzed with very high throughput. Typically, microfluidics is carried out within planar networks of microchannels, namely, microfluidic chips. We propose that fibers offer an interesting alternative format with key advantages for enhanced optical coupling. Herein, we demonstrate the generation of monodisperse droplets within a uniaxial optofluidic Lab-in-a-Fiber scheme. We combine droplet microfluidics with laser-induced fluorescence (LIF) detection achieved through the development of an optical side-coupling fiber, which we term a periscope fiber. This arrangement provides stable and compact alignment. Laser-induced fluorescence offers high sensitivity and low detection limits with a rapid response time making it an attractive detection method for in situ real-time measurements. We use the well-established fluorophore, fluorescein, to characterize the Lab-in-a-Fiber device and determine the generation of ∼ 0.9 nL droplets. We present characterization data of a range of fluorescein concentrations, establishing a limit of detection (LOD) of 10 nM fluorescein. Finally, we show that the device operates within a realistic and relevant fluorescence regime by detecting reverse-transcription loop-mediated isothermal amplification (RT-LAMP) products in the context of COVID-19 diagnostics. The device represents a step towards the development of a point-of-care droplet digital RT-LAMP platform. © 2022, The Author(s).

Place, publisher, year, edition, pages
Nature Research, 2022
Keywords
fluorescence, isolation and purification, lab on a chip, laser, virus, Lab-On-A-Chip Devices, Lasers, Viruses
National Category
Biochemistry and Molecular Biology
Identifiers
urn:nbn:se:ri:diva-58883 (URN)10.1038/s41598-022-07306-0 (DOI)2-s2.0-85125691313 (Scopus ID)
Note

Funding details: Office of Naval Research Global, ONRG, N62909-20-1-2033; Funding details: Knut och Alice Wallenbergs Stiftelse, 2016.0104; Funding details: Stiftelsen Lars Hiertas Minne; Funding text 1: This work was funded by a Knut and Alice Wallenberg Foundation Grant (2016.0104). W.M. acknowledges support by the Office of Naval Research Global (Award N62909-20-1-2033). 

Available from: 2022-03-30 Created: 2022-03-30 Last updated: 2023-03-27Bibliographically approved
Wilbur, S., Anastopoulos, C., Angelmahr, M., Asfis, G., Koch, J., Lindblom, M., . . . Margulis, W. (2022). Flexible X-ray imaging detectors using scintillating fibers. Journal of Instrumentation, 17(10), Article ID C10013.
Open this publication in new window or tab >>Flexible X-ray imaging detectors using scintillating fibers
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2022 (English)In: Journal of Instrumentation, ISSN 1748-0221, E-ISSN 1748-0221, Vol. 17, no 10, article id C10013Article in journal (Refereed) Published
Abstract [en]

We present early design and simulation work on a novel X-ray imaging detector. The intent of the FleX-RAY project is to create a digital X-ray detector that is capable of producing high-resolution images, is flexible enough to produce an image on a curved surface, and is capable of self-reporting its final shape. The X-rays will be detected on a sheet of scintillating optical fibers, which will guide the scintillation light to single-photon avalanche photodiodes. This setup allows the electronics and hardware to be moved out of the path of the X-ray beam, limiting the need for additional shielding. Self-shape-reporting will be achieved using a flexible ultra-thin glass substrate with optical waveguides and Bragg gratings, processed by femtosecond laser point-by-point writing. The functionalized glass substrate allows precise measurement of strains, which can be used to calculate the shape. © 2022 The Author(s).

Place, publisher, year, edition, pages
Institute of Physics, 2022
Keywords
Inspection with gamma rays, Inspection with X-rays, Scintillators, scintillation and light emission processes (solid, gas and liquid scintillators), X-ray detectors, Gamma rays, Glass, Glass substrates, Ionization, Optical fibers, Particle beams, Scintillation counters, X ray detectors, Early designs, Emission process, Gamma-rays, Inspection with gamma ray, Inspection with X-ray, Liquid scintillator, Scintillating fiber, Scintillator, scintillation and light emission process (solid, gas and liquid scintillator), X-ray detector, X-ray imaging detector, Scintillation
National Category
Engineering and Technology
Identifiers
urn:nbn:se:ri:diva-61396 (URN)10.1088/1748-0221/17/10/C10013 (DOI)2-s2.0-85140081513 (Scopus ID)
Note

This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programunder Grant Agreement No. 899634

Available from: 2022-12-08 Created: 2022-12-08 Last updated: 2023-10-31Bibliographically approved
Pereira, J., Tarasenko, O., Claesson, Å., Laurell, F. & Margulis, W. (2022). Optical poling by means of electrical corona discharge. Optics Express, 30(12), 20605-20613
Open this publication in new window or tab >>Optical poling by means of electrical corona discharge
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2022 (English)In: Optics Express, E-ISSN 1094-4087, Vol. 30, no 12, p. 20605-20613Article in journal (Refereed) Published
Abstract [en]

Electrical corona discharge is employed in this work to deposit ions on the surface of an optical fiber, creating a strong electric field that is used for poling. Green laser light propagating in the core frees photocarriers that are displaced by the poling field. The technique presented can induce a higher optical nonlinearity than previously obtained in traditional optical poling with internal metal electrodes. To date, a maximum second order nonlinearity 0.13 pm/V has been achieved for a 15 kV corona discharge bias. 

Place, publisher, year, edition, pages
Optica Publishing Group (formerly OSA), 2022
Keywords
Nonlinear optics, Optical fibers, Corona discharges, Green laser light, High optical nonlinearities, Metal electrodes, Optical poling, Photo-carriers, Poling field, Second-order nonlinearity, Strong electric fields, Electric corona
National Category
Atom and Molecular Physics and Optics
Identifiers
urn:nbn:se:ri:diva-59326 (URN)10.1364/OE.458459 (DOI)2-s2.0-85131262162 (Scopus ID)
Note

Funding details: Office of Naval Research Global, ONRG, N62909-20-1-2033; Funding details: Vetenskapsrådet, VR; Funding text 1: Horizon 2020 Framework Programme (ITN-FINESSE 722509); Marcus och Amalia Wallenbergs minnesfond; Vetenskapsrådet; Office of Naval Research Global (N62909-20-1-2033). The authors thank Åsa Claesson, Håkan Olsson, Mats Erikson and the Fiberlab group for the fibers used in the work.

Available from: 2022-06-20 Created: 2022-06-20 Last updated: 2023-06-08Bibliographically approved
Amorebieta, J., Pereira, J., Durana, G., Franciscangelis, C., Ortega-Gomez, A., Zubia, J., . . . Margulis, W. (2022). Twin-core fiber sensor integrated in laser cavity. Scientific Reports, 12(1), Article ID 11797.
Open this publication in new window or tab >>Twin-core fiber sensor integrated in laser cavity
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2022 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 12, no 1, article id 11797Article in journal (Refereed) Published
Abstract [en]

In this work, we report on a twin-core fiber sensor system that provides improved spectral efficiency, allows for multiplexing and gives low level of crosstalk. Pieces of the referred strongly coupled multicore fiber are used as sensors in a laser cavity incorporating a pulsed semiconductor optical amplifier (SOA). Each sensor has its unique cavity length and can be addressed individually by electrically matching the periodic gating of the SOA to the sensor’s cavity roundtrip time. The interrogator acts as a laser and provides a narrow spectrum with high signal-to-noise ratio. Furthermore, it allows distinguishing the response of individual sensors even in the case of overlapping spectra. Potentially, the number of interrogated sensors can be increased significantly, which is an appealing feature for multipoint sensing. © 2022, The Author(s).

Place, publisher, year, edition, pages
Nature Research, 2022
National Category
Engineering and Technology
Identifiers
urn:nbn:se:ri:diva-59821 (URN)10.1038/s41598-022-16103-8 (DOI)2-s2.0-85133894021 (Scopus ID)
Note

Funding details: 2020-00187; Funding details: Office of Naval Research Global, ONRG, N62909-20-1-2033; Funding details: Ministerio de Economía y Competitividad, MINECO, PGC2018-101997-B-I00, TEC2015-638263-C03-1-R; Funding details: Euskal Herriko Unibertsitatea, EHU; Funding details: Vetenskapsrådet, VR; Funding details: Ministerio de Ciencia e Innovación, MICINN, IT1452-22, KK 2021/00082, KK 2021/00092, PID2021-122505OB-C31, TED2021-129959B-C21; Funding details: European Regional Development Fund, ERDF; Funding text 1: This work was supported in part by the European Regional Development Fund, in part by the Ministerio de Economía y Competitividad under projects TEC2015-638263-C03-1-R and PGC2018-101997-B-I00, in part by Ministerio de Ciencia e Innovación: under projects PID2021-122505OB-C31 and TED2021-129959B-C21, in part by the Gobierno Vasco/Eusko Jaurlaritza under projects IT1452-22 and ELKARTEK (KK 2021/00082 and KK 2021/00092), in part by the Swedish Science Council, Office of Naval Research Global (Award N62909-20-1-2033) and in part by Vinnova Innovair: Forskningsprojekt inom flygteknik (D.N. 2020-00187). The work of Josu Amorebieta is funded by a PhD fellowship from the University of the Basque Country UPV/EHU. 

Available from: 2022-08-04 Created: 2022-08-04 Last updated: 2023-10-31Bibliographically approved
Colaço, M., Camara, A., Nogueira, L., Carvalho, I., Margulis, W. & Barroso, R. (2021). Characterization of the microstructures of specialty optical fibers for electric-field sensing by propagation-based x-ray phase-contrast microtomography. Measurement science and technology, 32(6), Article ID 065401.
Open this publication in new window or tab >>Characterization of the microstructures of specialty optical fibers for electric-field sensing by propagation-based x-ray phase-contrast microtomography
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2021 (English)In: Measurement science and technology, ISSN 0957-0233, E-ISSN 1361-6501, Vol. 32, no 6, article id 065401Article in journal (Refereed) Published
Abstract [en]

In this work, we present a quantitative (statistical) 3D morphological characterization of optical fibers used in electric-field sensing. The characterization technique employs propagation-based x-ray phase-contrast microcomputed tomography (micro-CT). In particular, we investigate specialty optical fibers that contain microstructured holes that are electro-optically modified by thermal poling to induce second-order nonlinear effects (SONE). The efficiency of the SONE is reflected in the characterization parameter, Vπ, which is highly dependent on the dimensions of the fiber. The fiber microstructures must be uniform to support the fabrication of reproducible devices. The results obtained using the micro-CT technique show that uncertainty of ±1.7% arises in the determination of the expected value of the voltage that causes a change in the phase of the electromagnetic wave equal to π rad (Vπ ), demonstrating a great advantage, compared with other techniques e.g. SEM, which would need at least 1000 images of the cross-section of an optical fiber, taken at different points, making the process more expensive and time-consuming.

Place, publisher, year, edition, pages
IOP Publishing Ltd, 2021
Keywords
optical fiber, phase contrast micro-CT, poling, synchrotron radiation, Electric fields, Microstructure, Optical fiber fabrication, Optical fibers, X rays, Characterization techniques, Electric field sensing, Fiber microstructures, Micro computed tomography (micro-CT), Morphological characterization, Second-order nonlinear effects, Specialty optical fibers, X ray phase contrast, Computerized tomography
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:ri:diva-53050 (URN)10.1088/1361-6501/abd365 (DOI)2-s2.0-85103839691 (Scopus ID)
Available from: 2021-05-25 Created: 2021-05-25 Last updated: 2021-05-25Bibliographically approved
Parker, H. E., Sengupta, S., Harish, A. V., Soares, R., Joensson, H. N., Margulis, W., . . . Laurell, F. (2021). Digital droplet microfluidic integrated lab-in-a-fiber detection of SARS-CoV-2 viral RNA. In: Optics InfoBase Conference Papers: . Paper presented at 2021 European Conference on Lasers and Electro-Optics, CLEO/Europe 2021, 21 June 2021 through 25 June 2021. The Optical Society
Open this publication in new window or tab >>Digital droplet microfluidic integrated lab-in-a-fiber detection of SARS-CoV-2 viral RNA
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2021 (English)In: Optics InfoBase Conference Papers, The Optical Society , 2021Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
The Optical Society, 2021
National Category
Infectious Medicine
Identifiers
urn:nbn:se:ri:diva-57351 (URN)2-s2.0-85120438466 (Scopus ID)9781557528209 (ISBN)
Conference
2021 European Conference on Lasers and Electro-Optics, CLEO/Europe 2021, 21 June 2021 through 25 June 2021
Available from: 2021-12-29 Created: 2021-12-29 Last updated: 2021-12-29Bibliographically approved
Margulis, W., Lindberg, R., Laurell, F. & Hedin, G. (2021). Intracavity interrogation of an array of fiber Bragg gratings. Optics Express, 29(1), 111-118
Open this publication in new window or tab >>Intracavity interrogation of an array of fiber Bragg gratings
2021 (English)In: Optics Express, E-ISSN 1094-4087, Vol. 29, no 1, p. 111-118Article in journal (Refereed) Published
Abstract [en]

In this work, we explore the interrogation of an array of fiber Bragg gratings as part of a laser cavity. A semiconductor optical amplifier in a sigma-shaped fiber cavity provides gain and is gated periodically at a rate that matches the roundtrip time associated with each grating of the array. The interrogator exhibits clear laser properties such as a threshold and linewidth narrowing. Besides improving the signal-to-noise ratio and enabling the re-use of wavelengths, it is found that this interrogation scheme enables monitoring of weak gratings spaced by less than 1 cm. Intracavity grating interrogation studied here is found to be a simple and powerful way to increase the number of sensor points for industrial applications. 

Place, publisher, year, edition, pages
OSA - The Optical Society, 2021
Keywords
Fiber Bragg gratings, Semiconductor optical amplifiers, Signal to noise ratio, Intracavities, Laser property, Linewidth narrowing, Round-trip time, Shaped fibers, Fiber amplifiers
National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-51929 (URN)10.1364/OE.414094 (DOI)2-s2.0-85099077274 (Scopus ID)
Note

Funding details: Knut och Alice Wallenbergs Stiftelse, 2019-02526; Funding text 1: Vetenskapsr?det (2015-04346); Knut och Alice Wallenbergs Stiftelse; Process Industrial IT and Automation (2019-02526).

Available from: 2021-01-20 Created: 2021-01-20 Last updated: 2022-09-15Bibliographically approved
Pereira, J., Claesson, Å., Laurell, F., Tarasenko, O. & Margulis, W. (2021). Poling optical fibers with electrical corona discharge. In: Optics InfoBase Conference Papers: . Paper presented at 2021 European Conference on Lasers and Electro-Optics, CLEO/Europe 2021, 21 June 2021 through 25 June 2021. The Optical Society
Open this publication in new window or tab >>Poling optical fibers with electrical corona discharge
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2021 (English)In: Optics InfoBase Conference Papers, The Optical Society , 2021Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
The Optical Society, 2021
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
urn:nbn:se:ri:diva-57354 (URN)2-s2.0-85120409101 (Scopus ID)9781557528209 (ISBN)
Conference
2021 European Conference on Lasers and Electro-Optics, CLEO/Europe 2021, 21 June 2021 through 25 June 2021
Note

Funding text 1: Financial support from FINESSE (H2020 Marie Sklodowska Curie n. 722509), K. A. Wallenberg Foundation and the Swedish Science Council is acknowledged.

Available from: 2021-12-29 Created: 2021-12-29 Last updated: 2023-06-08Bibliographically approved
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Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0001-8058-2140

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