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Publications (8 of 8) Show all publications
Berglin, M., Cavanagh, J. P., Caous, J. S., Thakkar, B. S., Vasquez, J. M., Stensen, W., . . . Svenson, J. (2024). Flexible and Biocompatible Antifouling Polyurethane Surfaces Incorporating Tethered Antimicrobial Peptides through Click Reactions. Macromolecular Bioscience, 4, Article ID 2300425.
Open this publication in new window or tab >>Flexible and Biocompatible Antifouling Polyurethane Surfaces Incorporating Tethered Antimicrobial Peptides through Click Reactions
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2024 (English)In: Macromolecular Bioscience, ISSN 1616-5187, E-ISSN 1616-5195, Vol. 4, article id 2300425Article in journal (Refereed) Published
Abstract [en]

Efficient, simple antibacterial materials to combat implant-associated infections are much in demand. Herein, the development of polyurethanes, both cross-linked thermoset and flexible and versatile thermoplastic, suitable for “click on demand” attachment of antibacterial compounds enabled via incorporation of an alkyne-containing diol monomer in the polymer backbone, is described. By employing different polyolic polytetrahydrofurans, isocyanates, and chain extenders, a robust and flexible material comparable to commercial thermoplastic polyurethane is prepared. A series of short synthetic antimicrobial peptides are designed, synthesized, and covalently attached in a single coupling step to generate a homogenous coating. The lead material is shown to be biocompatible and does not display any toxicity against either mouse fibroblasts or reconstructed human epidermis according to ISO and OECD guidelines. The repelling performance of the peptide-coated materials is illustrated against colonization and biofilm formation by Staphylococcus aureus and Staphylococcus epidermidis on coated plastic films and finally, on coated commercial central venous catheters employing LIVE/DEAD staining, confocal laser scanning microscopy, and bacterial counts. This study presents the successful development of a versatile and scalable polyurethane with the potential for use in the medical field to reduce the impact of bacterial biofilms. 

Place, publisher, year, edition, pages
John Wiley and Sons Inc, 2024
Keywords
Bacteria; Biocompatibility; Biofilms; Cell culture; Coated materials; Crosslinking; Peptides; Plastic coatings; Reinforced plastics; Anti-foulings; Antibacterial materials; Antimicrobial peptide; Biocompatible; Click chemistry; Click reaction; Flexible; Implant-associated infection; On demands; Simple++; Polyurethanes
National Category
Polymer Chemistry Biomaterials Science Polymer Technologies
Identifiers
urn:nbn:se:ri:diva-68814 (URN)10.1002/mabi.202300425 (DOI)2-s2.0-85178409798 (Scopus ID)
Note

This study was financed by Amicoat A/S. The authors are grateful for the analytical assistance from RISE scientists L. Brive, P. Borchardt, K. Johansson, and J. Somertune.

Available from: 2024-01-08 Created: 2024-01-08 Last updated: 2024-05-23Bibliographically approved
Granskog, V., García-Gallego, S., von Kieseritzky, J., Rosendahl, J., Stenlund, P., Zhang, Y., . . . Malkoch, M. (2018). High-Performance Thiol–Ene Composites Unveil a New Era of Adhesives Suited for Bone Repair. Advanced Functional Materials, 28(26), Article ID 1800372.
Open this publication in new window or tab >>High-Performance Thiol–Ene Composites Unveil a New Era of Adhesives Suited for Bone Repair
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2018 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Vol. 28, no 26, article id 1800372Article in journal (Refereed) Published
Abstract [en]

The use of adhesives for fracture fixation can revolutionize the surgical procedures toward more personalized bone repairs. However, there are still no commercially available adhesive solutions mainly due to the lack of biocompatibility, poor adhesive strength, or inadequate fixation protocols. Here, a surgically realizable adhesive system capitalizing on visible light thiol–ene coupling chemistry is presented. The adhesives are carefully designed and formulated from a novel class of chemical constituents influenced by dental resin composites and self-etch primers. Validation of the adhesive strength is conducted on wet bone substrates and accomplished via fiber-reinforced adhesive patch (FRAP) methodology. The results unravel, for the first time, on the promise of a thiol–ene adhesive with an unprecedented shear bond strength of 9.0 MPa and that surpasses, by 55%, the commercially available acrylate dental adhesive system Clearfil SE Bond of 5.8 MPa. Preclinical validation of FRAPs on rat femur fracture models details good adhesion to the bone throughout the healing process, and are found biocompatible not giving rise to any inflammatory response. Remarkably, the FRAPs are found to withstand loads up to 70 N for 1000 cycles on porcine metacarpal fractures outperforming clinically used K-wires and match metal plates and screw implants.

Keywords
adhesives, biomedical applications, composites, photochemistry, polymeric materials, Biocompatibility, Composite materials, Dental composites, Dental materials, Fracture, Fracture fixation, Functional polymers, Medical applications, Photochemical reactions, Polymeric implants, Polymers, Chemical constituents, Coupling chemistry, Dental adhesive system, Dental resin composites, Inflammatory response, Shear bond strengths, Surgical procedures, Bone
National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-33958 (URN)10.1002/adfm.201800372 (DOI)2-s2.0-85048981911 (Scopus ID)
Note

Funding details: KI, Karolinska Institutet; Funding details: MSCA-IF-2014-655649, MSCA, H2020 Marie Skłodowska-Curie Actions; Funding details: 2010-435; Funding details: 2014-03777; Funding details: 2012-0196, Knut och Alice Wallenbergs Stiftelse; 

Available from: 2018-07-03 Created: 2018-07-03 Last updated: 2024-05-21Bibliographically approved
Svensson, S., Suska, F., Emanuelsson, L., Palmquist, A., Norlindh, B., Trobos, M., . . . Thomsen, P. (2013). Osseointegration of titanium with an antimicrobial nanostructured noble metal coating (ed.). Nanomedicine: Nanotechnology, Biology, and Medicine, 9(7), 1048-1056
Open this publication in new window or tab >>Osseointegration of titanium with an antimicrobial nanostructured noble metal coating
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2013 (English)In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 9, no 7, p. 1048-1056Article in journal (Refereed) Published
Abstract [en]

Nanometer scale surface features on implants and prostheses can potentially be used to enhance osseointegration and may also add further functionalities, such as infection resistance, to the implant. In this study, a nanostructured noble metal coating consisting of palladium, gold and silver, never previously used in bone applications, was applied to machined titanium screws to evaluate osseointegration after 6 and 12. weeks in rabbit tibiae and femurs. Infection resistance was confirmed by in vitro adhesion test. A qualitatively and quantitatively similar in vivo bone response was observed for the coated and uncoated control screws, using histology, histomorphometry and electron microscopy. The bone-implant interface analysis revealed an extensive bone formation and direct bone-implant contact. These results demonstrate that the nanostructured noble metal coating with antimicrobial properties promotes osseointegration and may therefore be used to add extra implant functionality in the form of increased resistance to infection without the use of antibiotics. From the Clinical Editor: The authors of this paper demonstrate that nanostructured noble metal coating of implants and prostheses used in orthopedic procedures promotes osseointegration and may be used to add extra implant functionality in the form of increased resistance to infection without the use of antibiotics.

Keywords
Antimicrobial, Nanotopography, Noble metals, Osseointegration, Titanium
National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-6533 (URN)10.1016/j.nano.2013.04.009 (DOI)2-s2.0-84884287103 (Scopus ID)23811 (Local ID)23811 (Archive number)23811 (OAI)
Available from: 2016-09-08 Created: 2016-09-08 Last updated: 2024-05-21Bibliographically approved
Lyvén, B. & Haraldsson, C. (2003). Competition between iron- and carbon-based colloidal carriers for trace metals in a freshwater assessed using flow field-flow fractionation coupled to ICPMS (ed.). Geochimica et Cosmochimica Acta, 67, 3791-3802
Open this publication in new window or tab >>Competition between iron- and carbon-based colloidal carriers for trace metals in a freshwater assessed using flow field-flow fractionation coupled to ICPMS
2003 (English)In: Geochimica et Cosmochimica Acta, Vol. 67, p. 3791-3802Article in journal (Refereed) Published
Abstract [en]

Competition between iron- and carbon-based colloidal carriers for trace metals in a freshwater assessed using flow field-flow fractionation coupled to ICPMS

National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-5855 (URN)2195 (Local ID)2195 (Archive number)2195 (OAI)
Available from: 2016-09-08 Created: 2016-09-08 Last updated: 2024-05-21Bibliographically approved
Möller, K. & Lyvén, B. (2002). Chemical and topographical analyses of tooth surfaces after Carisolv treatment (ed.). Journal of Dentistry, 30(2), 67-75
Open this publication in new window or tab >>Chemical and topographical analyses of tooth surfaces after Carisolv treatment
2002 (English)In: Journal of Dentistry, ISSN 0300-5712, E-ISSN 1879-176X, Vol. 30, no 2, p. 67-75Article in journal (Other academic) Published
National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-5821 (URN)1988 (Local ID)1988 (Archive number)1988 (OAI)
Available from: 2016-09-08 Created: 2016-09-08 Last updated: 2024-05-21Bibliographically approved
Lyvén, B. (2001). Mobility and methylation of mercury in forest soils (ed.). Water Air and Soil Pollution: Focus 1, 285-393
Open this publication in new window or tab >>Mobility and methylation of mercury in forest soils
2001 (English)In: Water Air and Soil Pollution: Focus 1, p. 285-393Article in journal (Other academic) Published
National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-5805 (URN)1861 (Local ID)1861 (Archive number)1861 (OAI)
Available from: 2016-09-08 Created: 2016-09-08 Last updated: 2024-05-21Bibliographically approved
Lyvén, B. (2001). Particle size distributions of clay-rich sediments and pure cly minerals: A comparison of grain size analysis with sedimentation field-flow fractionation (ed.). Aquatic geochemistry, 7(2), 155-171
Open this publication in new window or tab >>Particle size distributions of clay-rich sediments and pure cly minerals: A comparison of grain size analysis with sedimentation field-flow fractionation
2001 (English)In: Aquatic geochemistry, ISSN 1380-6165, E-ISSN 1573-1421, Vol. 7, no 2, p. 155-171Article in journal (Other academic) Published
National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-5801 (URN)1854 (Local ID)1854 (Archive number)1854 (OAI)
Available from: 2016-09-08 Created: 2016-09-08 Last updated: 2024-05-21Bibliographically approved
Lyvén, B., Haraldsson, C. & Hassellöv, M. (1999). Determination of continuous size and trace element distribution of colloidal material in natural water by online coupling of flow field-flow fractionation with ICP MS (ed.). Analytical Chemistry, 71(16), 3497-3502
Open this publication in new window or tab >>Determination of continuous size and trace element distribution of colloidal material in natural water by online coupling of flow field-flow fractionation with ICP MS
1999 (English)In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 71, no 16, p. 3497-3502Article in journal (Other academic) Published
National Category
Natural Sciences
Identifiers
urn:nbn:se:ri:diva-5729 (URN)1451 (Local ID)1451 (Archive number)1451 (OAI)
Available from: 2016-09-08 Created: 2016-09-08 Last updated: 2024-05-21Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0009-0004-4460-1956

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