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Publications (10 of 16) Show all publications
Kroner, C., Warnecke, H., Büker, O., Stolt, K., Wennergren, P., Hagemann, G. & Werner, M. (2024). Metrology for reliable fuel consumption measurements in the maritime sector. Measurement, 226, Article ID 114161.
Open this publication in new window or tab >>Metrology for reliable fuel consumption measurements in the maritime sector
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2024 (English)In: Measurement, ISSN 0263-2241, E-ISSN 1873-412X, Vol. 226, article id 114161Article in journal (Refereed) Published
Abstract [en]

Reliable fuel consumption measurements play an essential role in the maritime sector whether for emission determinations or the use of novel fuels. A verification of the performance of flow meters used for fuel consumption determination under realistic conditions is thus of interest. Apart from the influence of the pressure- and temperature-dependent transport properties of the fuels, a characterization of the measurement performance under dynamic fuel consumption is of relevance. Traceable metrological infrastructure and procedures, which will enable an evaluation of the measurement performance of flow meters in this regard, are being developed in the scope of the EMPIR project “Safest” (20IND13). A consumption profile of a ferry navigating in a harbour serves as basis. In addition to the measurement accuracy under dynamic conditions, first investigations of the performance of flow meters are carried out in terms of fluid temperature and fuel transport properties for the example of spindle screw meters.

Place, publisher, year, edition, pages
Elsevier B.V., 2024
Keywords
Dynamic flows, Flow measurements, Fuel consumption, Measurement uncertainty, Transport properties, Flowmeters, Uncertainty analysis, Consumption measurement, Flow meter, Maritime sector, Novel fuels, Performance, Pressure and temperature, Pressure dependent, Realistic conditions, Flow measurement
National Category
Mechanical Engineering
Identifiers
urn:nbn:se:ri:diva-71949 (URN)10.1016/j.measurement.2024.114161 (DOI)2-s2.0-85182916299 (Scopus ID)
Funder
EU, Horizon 2020European Metrology Programme for Innovation and Research (EMPIR)
Note

This project (EMPIR JRP 20IND13 SAFEST) has received funding from the EMPIR programme co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation programme.

Available from: 2024-02-27 Created: 2024-02-27 Last updated: 2024-05-17Bibliographically approved
Niemann, A., Batista, E., Geršl, J., Bissig, H., Büker, O., Lee, S., . . . Knotek, S. (2023). Assessment of drug delivery devices working at microflow rates. Biomedizinische Technik (Berlin. Zeitschrift), 68(1), 51-65
Open this publication in new window or tab >>Assessment of drug delivery devices working at microflow rates
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2023 (English)In: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 68, no 1, p. 51-65Article in journal (Refereed) Published
Abstract [en]

Almost every medical department in hospitals around the world uses infusion devices to administer fluids, nutrition, and medications to patients to treat many different diseases and ailments. There have been several reports on adverse incidents caused by medication errors associated with infusion equipment. Such errors can result from malfunction or improper use, or even inaccuracy of the equipment, and can cause harm to patients' health. Depending on the intended use of the equipment, e.g. if it is used for anaesthesia of adults or for medical treatment of premature infants, the accuracy of the equipment may be more or less important. A well-defined metrological infrastructure can help to ensure that infusion devices function properly and are as accurate as needed for their use. However, establishing a metrological infrastructure requires adequate knowledge of the performance of infusion devices in use. This paper presents the results of various tests conducted with two types of devices. © 2022 the author(s)

Place, publisher, year, edition, pages
De Gruyter Open Ltd, 2023
Keywords
calibration, infusion device, metrological infrastructure, microflow, Drug delivery devices, Infusion devices, Medical treatment, Medication errors, Micro-flow, Micro-flow rates, Patient health, Performance, Premature infants, Drug delivery
National Category
Engineering and Technology
Identifiers
urn:nbn:se:ri:diva-61596 (URN)10.1515/bmt-2022-0053 (DOI)2-s2.0-85143083194 (Scopus ID)
Note

Funding details: Horizon 2020 Framework Programme, H2020; Funding details: European Metrology Programme for Innovation and Research, EMPIR; Funding text 1: Research funding: This work performed under the 18HLT08 MeDD II project has received funding from the EMPIR program co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation program. For more information on the project refer to the website www.drugmetrology.com .

Available from: 2022-12-19 Created: 2022-12-19 Last updated: 2024-04-17Bibliographically approved
Mills, C., Batista, E., Bissig, H., Ogheard, F., Boudaoud, A., Büker, O., . . . Lötters, J. (2023). Calibration methods for flow rates down to 5 nL/min and validation methodology. Biomedizinische Technik (Berlin. Zeitschrift), 68(1), 13-27
Open this publication in new window or tab >>Calibration methods for flow rates down to 5 nL/min and validation methodology
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2023 (English)In: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 68, no 1, p. 13-27Article in journal (Refereed) Published
Abstract [en]

Improving the accuracy and enabling traceable measurements of volume, flow, and pressure in existing drug delivery devices and in-line sensors operating at very low flow rates is essential in several fields of activities and specially in medical applications. This can only be achieved through the development of new calibration methods and by expanding the existing metrological infrastructure to perform micro-flow and nano-flow measurements. In this paper, we will investigate new traceable techniques for measuring flow rate, from 5 nL/min to 1,500 nL/min and present the results of an inter-comparison between nine laboratories for the calibration of two different flow meters and a syringe pump. 

Place, publisher, year, edition, pages
De Gruyter Open Ltd, 2023
Keywords
comparison, flow meter, measurement, micro-flow, nano-flow, traceability, uncertainty
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
urn:nbn:se:ri:diva-60086 (URN)10.1515/bmt-2022-0049 (DOI)2-s2.0-85136550798 (Scopus ID)
Note

Funding details: Horizon 2020 Framework Programme, H2020; Funding details: European Metrology Programme for Innovation and Research, EMPIR; Funding text 1: Research funding: EMPIR programme co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation programme.

Available from: 2022-09-09 Created: 2022-09-09 Last updated: 2024-04-17Bibliographically approved
Bissig, H., Büker, O., Stolt, K., Batista, E., Afonso, J., Zagnoni, M., . . . Schroeter, J. (2023). Calibration of insulin pumps based on discrete doses at given cycle times. Biomedizinische Technik (Berlin. Zeitschrift), 68(1), 67-77
Open this publication in new window or tab >>Calibration of insulin pumps based on discrete doses at given cycle times
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2023 (English)In: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 68, no 1, p. 67-77Article in journal (Refereed) Published
Abstract [en]

One application in the medical treatment at very small flow rates is the usage of an Insulin pump that delivers doses of insulin at constant cycle times for a specific basal rate as quasi-continuous insulin delivery, which is an important cornerstone in diabetes management. The calibration of these basal rates are performed by either gravimetric or optical methods, which have been developed within the European Metrology Program for Innovation and Research (EMPIR) Joint Research Project (JRP) 18HLT08 Metrology for drug delivery II (MeDDII). These measurement techniques are described in this paper, and an improved approach of the analytical procedure given in the standard IEC 60601-2-24:2012 for determining the discrete doses and the corresponding basal rates is discussed in detail. These improvements allow detailed follow up of dose cycle time and delivered doses as a function of time to identify some artefacts of the measurement method or malfunctioning of the insulin pump. Moreover, the calibration results of different basal rates and bolus deliveries for the gravimetric and the optical methods are also presented. Some analysis issues that should be addressed to prevent misinterpreting of the calibration results are discussed. One of the main issues is the average over a period of time which is an integer multiple of the cycle time to determine the basal rate with the analytical methods described in this paper. 

Place, publisher, year, edition, pages
De Gruyter Open Ltd, 2023
Keywords
calibration, dose accuracy, insulin pump, traceability, Controlled drug delivery, Insulin, Pumps, Targeted drug delivery, Cycle time, Diabetes management, Insulin delivery, Insulin pumps, Medical treatment, Optical methods, Pump-based, Small flow-rate
National Category
Clinical Medicine
Identifiers
urn:nbn:se:ri:diva-61247 (URN)10.1515/bmt-2022-0040 (DOI)2-s2.0-85139486442 (Scopus ID)
Note

Funding details: Horizon 2020 Framework Programme, H2020; Funding details: European Metrology Programme for Innovation and Research, EMPIR; Funding text 1: Research funding: This project 18HLT08 MEDDII has received funding from the EMPIR programme co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation programme.

Available from: 2022-11-30 Created: 2022-11-30 Last updated: 2024-04-17Bibliographically approved
Büker, O., Stolt, K., Kroner, C., Warnecke, H., Postrioti, L., Piano, A., . . . Werner, M. (2023). Characterisation of a Coriolis flow meter for fuel consumption measurements in realistic drive cycle tests. Flow Measurement and Instrumentation, 93, Article ID 102424.
Open this publication in new window or tab >>Characterisation of a Coriolis flow meter for fuel consumption measurements in realistic drive cycle tests
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2023 (English)In: Flow Measurement and Instrumentation, ISSN 0955-5986, E-ISSN 1873-6998, Vol. 93, article id 102424Article in journal (Refereed) Published
Abstract [en]

When testing light-duty and heavy-duty vehicles on chassis dynamometers, as in the WLTP, or engines on engine test benches, as in the WHDC, it is required to measure the fuel consumption. In the preferable case, the measurement of the fuel consumption is carried out with suitable flow meters. These require high measurement accuracy in a wide flow range, independent of the fuel type, as the flow rate range is often very large and depends on the power range of the vehicle engines. Moreover, the fuel flow rate in the test cycles is very dynamically related to the loads. In the scope of the ongoing EMPIR Joint Research Project 20IND13 SAFEST the dynamic flow behaviour as well as the measurement accuracy of flow meters for different types of fuels are investigated. This paper presents first results from the realisation of dynamic flow profiles, and flow measurements with a Coriolis Flow Meter with different representative fuels in a wide density and viscosity range and a wide flow rate range at different fuel temperatures. © 2023 The Author(s)

Place, publisher, year, edition, pages
Elsevier Ltd, 2023
Keywords
Density, Dynamic flow, Fuel consumption, Viscosity, WHDC, WLTP, Dynamometers, Engines, Flow measurement, Flow rate, Flowmeters, Consumption measurement, Coriolis flowmeters, Cycle tests, Drive cycles, Dynamic flows, Flow meter, Measurement accuracy
National Category
Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
urn:nbn:se:ri:diva-65970 (URN)10.1016/j.flowmeasinst.2023.102424 (DOI)2-s2.0-85166283603 (Scopus ID)
Note

Correspondence Address: O. Büker, RISE, Sweden;  

The authors would like to thank Endress+Hauser (E+H) Flowtec AG in Switzerland for the Proline Promass A 500 Coriolis Flow Meter and the heating jacket, which were made available as in-kind contributions to the project. The authors are also grateful to Special Fuels Preem AB in Sweden for providing the biodiesel fuels. This project (20IND13 SAFEST) has received funding from the EMPIR programme co-financed by the Participating States and from the European Union's Horizon 2020 research and innovation programme

Available from: 2023-08-23 Created: 2023-08-23 Last updated: 2024-04-17Bibliographically approved
Jönsson, G., Büker, O. & Stolt, K. (2023). Gas flow measurement of evaporated liquid nanoflows. Measurement, 216
Open this publication in new window or tab >>Gas flow measurement of evaporated liquid nanoflows
2023 (English)In: Measurement, ISSN 0263-2241, E-ISSN 1873-412X, Vol. 216Article in journal (Refereed) Published
Abstract [en]

Following the miniaturisation of fluidic components, the demand for traceable measurements of micro and nanoflows is increasing in various technological fields such as pharmaceuticals, biotechnology and automotive industry. Gravimetric flow measurement methods are accurate at microflows and above, but have a lower limit of about 5nLmin−1. Several alternative approaches have been developed to circumvent this limit. Here a measurement setup and proof of principle is presented for a method measuring the gas flows generated by complete evaporation of liquid ethanol nanoflows. The gas flow measurement is based on the well-established method of determining the pressure drop across a geometrically precisely defined circular opening in the molecular flow regime. Liquid flow rates from a syringe pump in the range of 5nLmin−1 to 200nLmin−1 are measured with an expanded uncertainty as low as 340pLmin−1 at instantaneous flow rates. Strategies to further improve accuracy are discussed.

Keywords
Microflow, Nanoflow, Vacuum, Molecular flow, Ethanol
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:ri:diva-64420 (URN)10.1016/j.measurement.2023.112927 (DOI)S0263224123004918 (Scopus ID)
Funder
Vinnova, 2020-04318
Note

The financial support by the Sweden’s Innovation Agency (VINNOVA) , grant number 2020-04318, is gratefully acknowledged.

Available from: 2023-05-08 Created: 2023-05-08 Last updated: 2024-04-17Bibliographically approved
Bissig, H., Büker, O., Stolt, K., Graham, E., Wales, L., Furtado, A., . . . Lotters, J. C. (2023). In-line measurements of the physical and thermodynamic properties of single and multicomponent liquids. Biomedizinische Technik (Berlin. Zeitschrift), 68(1), 39-50
Open this publication in new window or tab >>In-line measurements of the physical and thermodynamic properties of single and multicomponent liquids
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2023 (English)In: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 68, no 1, p. 39-50Article in journal (Refereed) Published
Abstract [en]

Microfluidic devices are becoming increasingly important in various fields of pharmacy, flow chemistry and healthcare. In the embedded microchannel, the flow rates, the dynamic viscosity of the transported liquids and the fluid dynamic properties play an important role. Various functional auxiliary components of microfluidic devices such as flow restrictors, valves and flow meters need to be characterised with liquids used in several microfluidic applications. However, calibration with water does not always reflect the behaviour of the liquids used in the different applications. Therefore, several National Metrology Institutes (NMI) have developed micro-pipe viscometers for traceable inline measurement of the dynamic viscosity of liquids used in flow applications as part of the EMPIR 18HLT08 MeDDII project. These micro-pipe viscometers allow the calibration of any flow device at different flow rates and the calibration of the dynamic viscosity of the liquid or liquid mixture used under actual flow conditions. The validation of the micro-pipe viscometers has been performed either with traceable reference oils or with different liquids typically administered in hospitals, such as saline and/or glucose solutions or even glycerol-water mixtures for higher dynamic viscosities. Furthermore, measurement results of a commercially available device and a technology demonstrator for the inline measurement of dynamic viscosity and density are presented in this paper. © 2022 the author(s)

Place, publisher, year, edition, pages
De Gruyter Open Ltd, 2023
Keywords
calibration, dynamic viscosity, micro-pipe viscometer, traceability, Flow rate, Flowmeters, Fluidic devices, Liquids, Microfluidics, Saline water, Thermodynamic properties, Viscometers, Viscosity, Viscosity measurement, Dynamic viscosities, Embedded microchannels, Flow chemistry, In-line measurements, Measurements of, Microfluidics devices, Multicomponent liquids, Thermodynamics property
National Category
Engineering and Technology
Identifiers
urn:nbn:se:ri:diva-61423 (URN)10.1515/bmt-2022-0039 (DOI)2-s2.0-85142069917 (Scopus ID)
Note

Funding details: Horizon 2020 Framework Programme, H2020; Funding details: European Metrology Programme for Innovation and Research, EMPIR; Funding text 1: Research funding: This project 18HLT08 MEDDII has received funding from the EMPIR programme co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation programme.

Available from: 2022-12-07 Created: 2022-12-07 Last updated: 2024-04-17Bibliographically approved
Büker, O. & Stolt, K. (2022). RISE Test Facilities for the Measurement of Ultra-Low Flow Rates and Volumes with a Focus on Medical Applications. Applied Sciences, 12(16), Article ID 8332.
Open this publication in new window or tab >>RISE Test Facilities for the Measurement of Ultra-Low Flow Rates and Volumes with a Focus on Medical Applications
2022 (English)In: Applied Sciences, E-ISSN 2076-3417, Vol. 12, no 16, article id 8332Article in journal (Refereed) Published
Abstract [en]

In the framework of the ongoing EMPIR JRP 18HLT08 Metrology for Drug Delivery (MeDDII), a main task is to improve dosing accuracy and enable traceable measurements of volume, flow and pressure of existing drug delivery devices and in-line sensors operating, in some cases, at ultra-low flow rates. This can be achieved by developing new calibration methods and by expanding existing metrological infrastructure. The MeDDII project includes, among other issues, investigations on fast changing flow rates, physical properties of liquid mixtures and occlusion phenomena to avoid inaccurate measurement results and thus improve patient safety. This paper describes the extension of an existing measurement facility at RISE and the design and construction of a new measurement facility to be able to carry out such investigations. The new measurement facility, which is based on the dynamic gravimetric method, is unique worldwide in respect of the lowest measurable flow rate. The gravimetric measuring principle is pushed to the limits of what is feasible. Here, the smallest changes in the ambient conditions have a large influence on the measurement accuracy. The new infrastructure can be used to develop and validate novel calibration procedures for existing drug delivery devices over a wide flow rate range. The extension of the measurement facilities also enables inline measurement of the pressure and the dynamic viscosity of Newtonian liquids. For this purpose, it is ensured that all measurements are traceable to primary standards. © 2022 by the authors.

Place, publisher, year, edition, pages
MDPI, 2022
Keywords
drug delivery, flow measurement, IDA, insulin pump, microflow, nanoflow, syringe pump
National Category
Mathematics
Identifiers
urn:nbn:se:ri:diva-60290 (URN)10.3390/app12168332 (DOI)2-s2.0-85137987406 (Scopus ID)
Note

 Funding details: Horizon 2020 Framework Programme, H2020; Funding details: European Association of National Metrology Institutes, EURAMET; Funding details: European Metrology Programme for Innovation and Research, EMPIR; Funding details: VINNOVA, 2014-05078; Funding text 1: The authors greatly acknowledge the financial support of Vinnova (Sweden’s Innovation Agency) project 2014-05078 as a basis for this work. This work was supported by the European Association of National Metrology Institutes (EURAMET) through the European Metrology Programme for Innovation and Research (EMPIR) Joint Research Project (JRP) 18HLT08 Metrology for Drug Delivery (MeDDII). The EMPIR initiative is co-funded by the European Union’s Horizon 2020 research and innovation programme and the EMPIR Participating States.

Available from: 2022-10-10 Created: 2022-10-10 Last updated: 2024-04-17Bibliographically approved
Büker, O., Stolt, K., Lindström, K., Wennergren, P., Penttinen, O. & Mattiasson, K. (2021). A unique test facility for calibration of domestic flow meters under dynamic flow conditions. Flow Measurement and Instrumentation, 79, Article ID 101934.
Open this publication in new window or tab >>A unique test facility for calibration of domestic flow meters under dynamic flow conditions
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2021 (English)In: Flow Measurement and Instrumentation, ISSN 0955-5986, E-ISSN 1873-6998, Vol. 79, article id 101934Article in journal (Refereed) Published
Abstract [en]

In the early nineties a hot water test facility was planned and constructed for calibration and testing of volume and flow meters at the National Volume Measurement Laboratory at RISE (formerly SP Technical Research Institute of Sweden). The main feature of the test facility is the capability to measure flow in a wide temperature and flow range with very high accuracy. The objective of the project, which was initiated in 1989, was to design equipment for calibration of flow meters with stable flow and temperature conditions. After many years of international debate whether static testing is adequate to represent the later more dynamic application of domestic water meters, the EMPIR project 17IND13 Metrology for real-world domestic water metering (“Metrowamet”) was launched in 2018. The project investigates the influence of dynamic flow testing on the measurement accuracy of different types of domestic flow meters. One of the main objectives of the project is the development of infrastructure to carry out dynamic flow measurements. The existing test facility at RISE was at the time of construction one of the best hot and cold-water test facilities in the world. Due to the Metrowamet project the test facility has been upgraded to meet the needs of an infrastructure for dynamic flow investigations. The first findings from dynamic consumption profile measurements are reported in this paper. © 2021 The Authors

Place, publisher, year, edition, pages
Elsevier Ltd, 2021
Keywords
Calibration, Domestic water meters, Dynamic flow measurement, Flow meter accuracy, Test facility, Flow measurement, Testing, Volume measurement, Water meters, Design equipments, Dynamic applications, Dynamic flow conditions, International debate, Measurement accuracy, Profile measurement, Technical research, Temperature conditions, Test facilities
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
urn:nbn:se:ri:diva-53013 (URN)10.1016/j.flowmeasinst.2021.101934 (DOI)2-s2.0-85105016515 (Scopus ID)
Note

 Funding details: Horizon 2020 Framework Programme, H2020; Funding details: European Metrology Programme for Innovation and Research, EMPIR; Funding text 1: This project 17IND13 Metrowamet has received funding from the EMPIR programme co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation programme .

Available from: 2021-05-26 Created: 2021-05-26 Last updated: 2024-05-17Bibliographically approved
Büker, O., Stolt, K., Kroner, C., Benkova, M., Pavlas, J. & Seypka, V. (2021). Investigations on the influence of total water hardness and ph value on the measurement accuracy of domestic cold water meters. Water, 13(19), Article ID 2701.
Open this publication in new window or tab >>Investigations on the influence of total water hardness and ph value on the measurement accuracy of domestic cold water meters
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2021 (English)In: Water, E-ISSN 2073-4441, Vol. 13, no 19, article id 2701Article in journal (Refereed) Published
Abstract [en]

In the framework of the ongoing EMPIR Joint Research Project (JRP) 17IND13 Metrology for real-world domestic water metering (Metrowamet), a main task is to investigate the influence of realistic operation conditions, that is, typical water qualities (suspended particles, degree of hardness, and pH value), on the measurement accuracy. For this purpose, two representative types of cold water meters were investigated in more detail. Initially, the cold water meters were calibrated and then subjected to an accelerated wear test with water of different pH values and degrees of hardness. The accelerated wear tests were designed to reproduce the realistic use and service life of a cold water meter. Subsequently, the cold water meters were re-calibrated to assess the influence of the different water qualities on the measurement accuracy. One of the results was that the measurement accuracy of the water meters investigated was not strongly affected by the water quality. The practical realisation and the measurement results are reported in this paper. © 2021 by the authors.

Place, publisher, year, edition, pages
MDPI, 2021
Keywords
Domestic water meters, Flow measurement, PH value, Total hardness, Wear test, Flowmeters, pH, Water quality, Wear of materials, Cold waters, Domestic water, Domestic water meter, Hardness values, Measurement accuracy, Real-world, Hardness, acceleration, accuracy assessment, calibration, cold water, design, suspended load
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
urn:nbn:se:ri:diva-57034 (URN)10.3390/w13192701 (DOI)2-s2.0-85116457954 (Scopus ID)
Note

Funding details: Horizon 2020 Framework Programme, H2020; Funding details: European Metrology Programme for Innovation and Research, EMPIR; Funding text 1: Funding: This project 17IND13 Metrowamet has received funding from the EMPIR programme co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation programme.

Available from: 2021-11-25 Created: 2021-11-25 Last updated: 2024-04-17Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-2334-065X

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