Change search
Link to record
Permanent link

Direct link
Nilsson Pingel, TorbenORCID iD iconorcid.org/0000-0003-1258-4448
Publications (4 of 4) Show all publications
Rudolph-Schöpping, G., Larsson, E., Nilsson Pingel, T., Guizar-Sicairos, M., Villanueva-Perez, P., Hall, S. & Lipnizki, F. (2024). Towards multiscale X-ray tomographic imaging in membrane science — A perspective. Journal of Membrane Science, 690, Article ID 122245.
Open this publication in new window or tab >>Towards multiscale X-ray tomographic imaging in membrane science — A perspective
Show others...
2024 (English)In: Journal of Membrane Science, ISSN 0376-7388, E-ISSN 1873-3123, Vol. 690, article id 122245Article in journal (Refereed) Published
Abstract [en]

Tomographic X-ray imaging techniques offer novel opportunities for studying membranes and membrane processes in 3D on a spatial resolution not seen before. Traditional 2D imaging techniques used to characterise membranes have limitations that can be overcome by tomographic X-ray imaging. Tomographic X-ray imaging can provide information in 2D/3D or 4D (3D plus time) on membranes, membrane modules, and membrane processes on a scale ranging from micro- to nanometre. They offer the possibility to uncover many fundamental issues related to membrane science, including the detection and monitoring of macroscopic biofilm formation, scaling, and cake build-up. High-resolution nanotomographic X-ray imaging enables even microscopic characterisations such as pore size distribution or pore network analysis. This Perspective paper introduces the tomographic X-ray imaging techniques with the most potential for membrane science: microtomography, nanotomography, holotomography, and ptychotomography, and presents their applications in the literature regarding the field of membrane science. Based on these findings and our experiences opportunities, challenges, and limitations of tomographic X-ray imaging techniques are discussed. It is concluded that in the near future tomographic X-ray imaging techniques will become increasingly common analytical techniques for membrane manufacturers, scientists, and users. 

Place, publisher, year, edition, pages
Elsevier B.V., 2024
Keywords
analytic method; biofilm; network analysis; phenomena and functions of biological membrane; pore size distribution; radiography; review; three-dimensional imaging; two-dimensional imaging
National Category
Materials Engineering
Identifiers
urn:nbn:se:ri:diva-67929 (URN)10.1016/j.memsci.2023.122245 (DOI)2-s2.0-85176120223 (Scopus ID)
Note

This work has been performed with support from Sweden's Innovation Agency under the project “Measurements of membrane fouling in lignocellulosic biorefineries by ptychotomography” ref. no. 2019-03613 and EIT Food co-funded by the European Union under the project “Precision Fermentation: From Biotechnology to Sustainable Nutrition, ref. no. 21063. We acknowledge the Paul Scherrer Institute, Villigen, Switzerland for providing of synchrotron radiation beamtime at the beamline cSAXS of the SLS under the proposal 20220560. Furthermore, we acknowledge the support in the image analysis and visualisation provided by the Quantification of Imaging Data from MAX IV (QIM) project at Lund University and the QuantIm hackathon at LINXS (Institute of Advanced Neutron and X-ray Science, Lund, Sweden). Finally, GRS would like to thank The Royal Physiographic Society in Lund for a young research travel grant”.

Available from: 2023-11-27 Created: 2023-11-27 Last updated: 2023-11-27Bibliographically approved
Carmona, P., Poulsen, J., Westergren, J., Nilsson Pingel, T., Röding, M., Lambrechts, E., . . . Loren, N. (2023). Controlling the structure of spin-coated multilayer ethylcellulose/hydroxypropylcellulose films for drug release.. International Journal of Pharmaceutics, 644, Article ID 123350.
Open this publication in new window or tab >>Controlling the structure of spin-coated multilayer ethylcellulose/hydroxypropylcellulose films for drug release.
Show others...
2023 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 644, article id 123350Article in journal (Refereed) Epub ahead of print
Abstract [en]

Porous phase-separated ethylcellulose/hydroxypropylcellulose (EC/HPC) films are used to control drug transport out of pharmaceutical pellets. Water-soluble HPC leaches out and forms a porous structure that controls the drug transport. Industrially, the pellets are coated using a fluidized bed spraying device, and a layered film exhibiting varying porosity and structure after leaching is obtained. A detailed understanding of the formation of the multilayered, phase-separated structure during production is lacking. Here, we have investigated multilayered EC/HPC films produced by sequential spin-coating, which was used to mimic the industrial process. The effects of EC/HPC ratio and spin speed on the multilayer film formation and structure were investigated using advanced microscopy techniques and image analysis. Cahn-Hilliard simulations were performed to analyze the mixing behavior. A gradient with larger structures close to the substrate surface and smaller structures close to the air surface was formed due to coarsening of the layers already coated during successive deposition cycles. The porosity of the multilayer film was found to vary with both EC/HPC ratio and spin speed. Simulation of the mixing behavior and in situ characterization of the structure evolution showed that the origin of the discontinuities and multilayer structure can be explained by the non-mixing of the layers.

Keywords
Cahn-Hilliard simulations, cellulose, confocal laser scanning microscope, electron microscopy, multilayer film, phase separation kinetics, phase separation mechanisms, porous film for controlled release
National Category
Food Science
Identifiers
urn:nbn:se:ri:diva-66152 (URN)10.1016/j.ijpharm.2023.123350 (DOI)37640089 (PubMedID)
Note

The Swedish Foundation for Strategic Research (SSF grant FID16-0013), the Swedish Research Council (VR grant 2018-03986), and the Swedish Research Council for Sustainable Development (grant 2019-01295) are gratefully acknowledged for the funding. AstraZeneca is acknowledged for the financial support and materials. Funding is acknowledged by the Fund for Scientific Research Flanders (grants I012020N & I000321N) and the Special Research Fund of Ghent University (grant BOF.COR.2022.0003.01). 

Available from: 2023-09-08 Created: 2023-09-08 Last updated: 2023-09-08Bibliographically approved
Niimi, J., Ahlinder, A., Nilsson Pingel, T., Niimi, C., Höglund, E., Öhgren, C., . . . Nielsen, T. (2023). Saltiness enhancement: Impact of acid added to bread with heterogeneously distributed sodium chloride. Lebensmittel-Wissenschaft + Technologie, 176, Article ID 114557.
Open this publication in new window or tab >>Saltiness enhancement: Impact of acid added to bread with heterogeneously distributed sodium chloride
Show others...
2023 (English)In: Lebensmittel-Wissenschaft + Technologie, ISSN 0023-6438, E-ISSN 1096-1127, Vol. 176, article id 114557Article in journal (Refereed) Published
Abstract [en]

The current global sodium consumption exceeds recommended daily intakes and there is a great need to reduce the sodium content in foods for a healthier society. The current study investigated the effect of combining sensory interaction principles and heterogeneous distribution of NaCl in bread on sensory properties, structure, and NaCl distribution. Breads were prepared in three different arrangements of NaCl distribution: homogenous, layered, and layered with lactic acid. Within each arrangement, four NaCl levels were tested. The breads were evaluated by a sensory panel for perceived saltiness, sourness, and qualitative texture, measured for stiffness, and the NaCl distribution was determined by X-ray fluorescence microscopy (XFM). Perceived saltiness was significantly enhanced in breads beyond heterogeneous NaCl distribution when lactic acid was added. Stiffness measurements were affected by layering of bread, the layers without NaCl were stiffer with an increase in overall salt concentration. The heterogeneous distribution of NaCl in layered breads could be visualised by XFM and textural consequences of layering bread are discussed. The current study demonstrates the potential of combining principles of pulsation of taste and sensory interactions together to enhance salt perception, and hence suggesting the approach as a possible further strategy for NaCl reduction in bread.

Place, publisher, year, edition, pages
Academic Press, 2023
Keywords
Heterogeneous salt distribution, Perception, Pulsation, Salt, Sensory interactions, Fluorescence microscopy, Food products, Lactic acid, Sensory perception, Stiffness, Textures, 'current, Heterogeneous distributions, Recommended daily intakes, Sensory panels, Sensory properties, Stiffness measurements, X-ray fluorescence microscopy, Sodium chloride
National Category
Food Science
Identifiers
urn:nbn:se:ri:diva-63980 (URN)10.1016/j.lwt.2023.114557 (DOI)2-s2.0-85147538587 (Scopus ID)
Note

Correspondence Address: Niimi J, RISE Research Institutes of Sweden, Sweden. Funding details: Västra Götalandsregionen, RUN 2020–00378; Funding details: VINNOVA, 2020–01824; Funding text 1: The measurements indicated only a little NaCl migration after baking, freezing, storage and thawing, since sharp changes in the chlorine signals were not observed, but rather a gradual transition between the layers (Fig. S6). Also, the signal did not drop to zero in the centre of the layers with no added NaCl. The amount of NaCl migration appeared to be so small that it is not expected to have a significant impact on the perceived saltiness of the breads. Additional measurements were performed using ICP-OES and IC to investigate if the migration of sodium is larger than the observed chlorine migration in the XFM measurements. The migration of sodium was similar or less to that of chlorine, which supported the conclusions drawn from the XFM results (for methodology and a summary of the ICP-OES/IC results see S2.0 and Table S2 in the supplementary material). Given that the ICP-OES/IC measurements showed that chlorine migrated in a similarly strong manner to sodium, it is reasonable to assume that the sodium distribution was adequately represented by chlorine. These measurements with XFM demonstrated its applicability in measuring chlorine ions in bread. Previous applications of XFM were on plant materials such as leaves, seedlings, barley grains, and rice kernels to measure distribution of ions such as zinc, calcium, potassium, and manganese among others. The results demonstrate that XFM can be a useful tool in confirming heterogenous distribution of chlorine ions of NaCl in processed food stuffs, such as breads.This study was performed under the project ReduSalt – Salt Reduction in Foods, a project funded by Sweden's Innovation Agency (Vinnova), grant number 2020–01824. The financial support by Region Västra Götaland, Sweden, grant number RUN 2020–00378, is also gratefully acknowledged.  Funding text 2: This study was performed under the project ReduSalt – Salt Reduction in Foods, a project funded by Sweden's Innovation Agency (Vinnova) , grant number 2020–01824 . The financial support by Region Västra Götaland, Sweden , grant number RUN 2020–00378 

Available from: 2023-02-22 Created: 2023-02-22 Last updated: 2024-03-25Bibliographically approved
Townsend, P., Nilsson Pingel, T., Loren, N., Gebäck, T., Olsson, E., Särkkä, A. & Röding, M. (2021). Tessellation-based stochastic modelling of 3D coating structures imaged with FIB-SEM tomography. Computational materials science, 197, Article ID 110611.
Open this publication in new window or tab >>Tessellation-based stochastic modelling of 3D coating structures imaged with FIB-SEM tomography
Show others...
2021 (English)In: Computational materials science, ISSN 0927-0256, E-ISSN 1879-0801, Vol. 197, article id 110611Article in journal (Refereed) Published
Abstract [en]

To facilitate printing, coatings are typically applied to paperboard used for packaging to provide a good surface for application. To optimise the performance of the coating, it is important to understand the relationship between the microstructure of the material and its mass transport properties. In this work, three samples of paperboard coating are imaged using combined focused ion beam and scanning electron microscope (FIB-SEM) tomography data appropriately segmented to characterise the internal microstructure. These images are used to inform a parametric, tessellation-based stochastic three-dimensional model intended to mimic the irregular geometry of the particles that can be seen in the coating. Parameters for the model are estimated from the FIB-SEM image data, and we demonstrate good agreement between the real and virtual structures both in terms of geometrical measures and mass transport properties. The development of this model facilitates exploration of the relationship between the structure and its properties. © 2021 The Author(s)

Place, publisher, year, edition, pages
Elsevier B.V., 2021
Keywords
FIB-SEM tomography, Gaussian random field, Laguerre tessellation, Paperboard coatings, Permeability, Stochastic modelling
National Category
Manufacturing, Surface and Joining Technology
Identifiers
urn:nbn:se:ri:diva-55217 (URN)10.1016/j.commatsci.2021.110611 (DOI)2-s2.0-85107658403 (Scopus ID)
Note

Funding details: 2019-01295; Funding details: Technische Universität Kaiserslautern, TU KL; Funding details: VINNOVA, 2018-00424; Funding details: Vetenskapsrådet, VR, 2016-03809, VR 2018-03986; Funding text 1: This work was financially supported by Vinnova (project number 2018-00424) as part of the CoSiMa project, as well as by the Swedish Research Council (VR 2018-03986 and 2016-03809) and the Swedish Research Council for Sustainable Development (2019-01295). The computations were in part performed on resources at Chalmers Centre for Computational Science and Engineering (C3SE) provided by the Swedish National Infrastructure for Computing (SNIC). The authors would like to thank Chris Bonnerup of StoraEnso and Magnus ?stlund of TetraPak for providing the coating samples used in this paper and for their helpful comments. The authors would also like to thank Claudia Redenbach and Katja Schladitz of the Technical University of Kaiserslautern and the Fraunhofer Institute for Industrial Mathematics for their hospitality and informative discussions during a research visit to Kaiserslautern.; Funding text 2: This work was financially supported by Vinnova (project number 2018-00424) as part of the CoSiMa project, as well as by the Swedish Research Council (VR 2018-03986 and 2016-03809) and the Swedish Research Council for Sustainable Development (2019-01295). The computations were in part performed on resources at Chalmers Centre for Computational Science and Engineering (C3SE) provided by the Swedish National Infrastructure for Computing (SNIC).

Available from: 2021-07-06 Created: 2021-07-06 Last updated: 2023-05-26Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-1258-4448

Search in DiVA

Show all publications